Treatments in Endocrinology

, Volume 1, Issue 1, pp 45–53

Potential Utility of Insulin Sensitizers in the Treatment of Patients with Polycystic Ovary Syndrome

  • Fahri Bayram
  • Kursad Unluhizarci
  • Fahrettin Kelestimur
Review Article

DOI: 10.2165/00024677-200201010-00005

Cite this article as:
Bayram, F., Unluhizarci, K. & Kelestimur, F. Mol Diag Ther (2002) 1: 45. doi:10.2165/00024677-200201010-00005

Abstract

Polycystic ovary syndrome (PCOS) is a form of functional ovarian hyperandrogenism. It is one of the most common endocrinologic disorders in women of reproductive age. Women with PCOS may present with menstrual irregularities, chronic anovulation, infertility, obesity and hyperandrogenism. PCOS is associated with insulin resistance and hyperinsulinemia in most, if not all, patients. Besides its gynecological manifestations, PCOS is also associated with increased metabolic and cardiovascular risks. These risks are strongly linked to insulin resistance, and during recent years a novel therapeutic approach using insulin-sensitizing agents has been extensively investigated.

In most studies conducted to date, metformin and the thiazolidinedione agent troglitazone have resulted in improved insulin sensitivity, resumption of regular menses and decreased serum androgen levels. Insulin-sensitizing agents may be a useful adjuvant therapy for women with PCOS.

Copyright information

© Adis Data Information BV 2002

Authors and Affiliations

  • Fahri Bayram
    • 1
  • Kursad Unluhizarci
    • 1
  • Fahrettin Kelestimur
    • 1
  1. 1.Department of Endocrinology ErciyesUniversity Medical SchoolKayseriTurkey