CNS Drugs

, Volume 15, Issue 12, pp 969–976

Frovatriptan

Adis New Drug Profile

DOI: 10.2165/00023210-200115120-00006

Cite this article as:
Easthope, S.E. & Goa, K.L. CNS Drugs (2001) 15: 969. doi:10.2165/00023210-200115120-00006

Abstract

  • ▴ Frovatriptan, a new serotonin receptor agonist developed for the acute treatment of migraine, has high affinity for serotonin 5-HT1B and 5-HT1D receptor subtypes and is a potent stimulator of contraction in human basilar arteries.

  • ▴ Along terminal elimination half-life (≈26 hours) is a distinctive pharmacokinetic feature of frovatriptan which appears to be independent of dose, age, gender and renal function.

  • ▴ A single oral dose of frovatriptan 2.5mg was effective in the acute treatment of migraine providing meaningful relief within 2 hours to approximately twice as many recipients as placebo in clinical trials.

  • ▴ Consistent relief of migraine symptoms was achieved in patients who treated a number of consecutive attacks with frovatriptan and the incidence of 24-hour migraine recurrence was reduced.

  • ▴ Frovatriptan was well tolerated in clinical trials, with the overall incidence of adverse events occurring with frovatriptan 2.5mg only slightly higher than that reported with placebo. Mild to moderate fatigue, nausea and paraesthesia were the most commonly reported drug-related adverse events

Copyright information

© Adis International Limited 2001

Authors and Affiliations

  1. 1.Adis International LimitedMairangi Bay, Auckland 10New Zealand