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- Haria, M. & Balfour, J.A. CNS Drugs (1997) 7: 159. doi:10.2165/00023210-199707020-00006
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▲ Levetiracetam is an ethyl analogue of the nootropic agent piracetam.
▲ Results from rodent studies indicate that the drug may offer protection against absence, generalised and partial seizures.
▲ Levetiracetam exhibits linear pharmacokinetics and has a wide therapeutic index. Its potential to interact with other anticonvulsants appears to be low.
▲ Initial findings from a total of 29 patients with treatment-refractory epilepsy suggest that levetiracetam may be beneficial in patients with partial seizures. These results require confirmation.
▲ Somnolence and asthenia were the most common adverse events reported in patients receiving levetiracetam 1000 to 4000 mg/day; these appeared to be dose-related.