PharmacoEconomics

, Volume 23, Issue 8, pp 777–790

Parent-proxy EQ-5D ratings of children with attention-deficit hyperactivity disorder in the US and the UK

  • Louis S. Matza
  • Kristina Secnik
  • Sally Mannix
  • F. Randy Sallee
Original Research Article

DOI: 10.2165/00019053-200523080-00004

Cite this article as:
Matza, L.S., Secnik, K., Mannix, S. et al. Pharmacoeconomics (2005) 23: 777. doi:10.2165/00019053-200523080-00004

Abstract

Background: The symptoms of attention-deficit hyperactivity disorder (ADHD) are associated with impairment in multiple domains of health-related quality of life (HR-QOL). HR-QOL of children with ADHD has been assessed by relatively long multidimensional questionnaires. A review of the literature found no studies using the brief, well established EuroQoL Five-Dimension Questionnaire (EQ-5D) to estimate the HR-QOL of children with ADHD. The objective of this study was to assess the HR-QOL of children with ADHD using parents’ responses to the proxy version of the EQ-5D.

Methods: Participants were recruited in the midwestern US and in the vicinity of London, England. All parents completed three questionnaires: the EQ-5D proxy version; a measure of ADHD symptoms based on Diagnostic and Statistical Manual of Mental Disorders (4th Edition) [DSM-IV] criteria (the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV — Parent Version [ADHD-RS]); and either the Child Health Questionnaire — Parent Form 50 (CHQ-PF50) or the Child Health and Illness Profile — Child Edition (CHIP-CE), which are both generic multidimensional paediatric HR-QOL questionnaires.

Results: A total of 126 parents of children with ADHD participated in the study: 43 in the US and 83 in the UK. On the EQ-5D, participants indicated that 78.6% of their children experienced some problems or extreme problems performing usual activities, while 64.8% believed their child demonstrated some or extreme anxiety or depression. The mean EQ-5D index score was 0.75 and the mean visual analogue scale (VAS) score was 73.9. The EQ-5D index and VAS scores were found to be significantly correlated (p < 0.05) with several domains of the CHQ-PF50 (e.g. Mental Health, Self-Esteem, Family Activities, Psychosocial Summary Score) and the CHIP-CE (e.g. Satisfaction, Comfort, Academic Performance, Peer Relations). The EQ-5D scales were also significantly correlated with the ADHD-RS scales (p < 0.001).

Conclusion: The proxy version of the EQ-5D, completed by parents, was able to detect impairment in children diagnosed with ADHD in the US and the UK. Furthermore, the EQ-5D index and VAS scores demonstrated construct validity among this sample through significant correlations with an ADHD symptom measure and previously validated multidimensional QOL instruments. These results suggest that parent-proxy EQ-5D ratings are feasible and valid for use as part of an overall health outcomes assessment in clinical studies of childhood ADHD.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  • Louis S. Matza
    • 1
  • Kristina Secnik
    • 2
  • Sally Mannix
    • 1
  • F. Randy Sallee
    • 3
  1. 1.The MEDTAP Institute at United BioSource Corporation (UBC)BethesdaUSA
  2. 2.Eli Lilly & CompanyIndianapolisUSA
  3. 3.Department of PsychiatryUniversity of CincinnatiCincinnatiUSA