The Use of the Bootstrap Statistical Method for the Pharmacoeconomic Cost Analysis of Skewed Data
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- Desgagné, A., Castilloux, AM., Angers, JF. et al. Pharmacoeconomics (1998) 13: 487. doi:10.2165/00019053-199813050-00002
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In pharmacoeconomics, the comparison of the costs of 2 different drugs used for the same treatment is of great interest. The problem is especially challenging when the drugs are likely to produce costly adverse effects in a small number of patients, which is often the case. The data are then skewed and traditional statistical methods to analyse the difference in the mean costs produced by 2 treatments may be inappropriate. The bootstrap method is presented as an alternative approach. A pharmacoeconomic cost-analysis example is presented and used throughout this article.