Sports Medicine

, Volume 38, Issue 2, pp 139–160

Mechanotransduction in Human Bone

In Vitro Cellular Physiology that Underpins Bone Changes with Exercise
  • Alexander Scott
  • Karim M. Khan
  • Vincent Duronio
  • David A. Hart
Review Article

DOI: 10.2165/00007256-200838020-00004

Cite this article as:
Scott, A., Khan, K.M., Duronio, V. et al. Sports Med (2008) 38: 139. doi:10.2165/00007256-200838020-00004

Abstract

Bone has a remarkable ability to adjust its mass and architecture in response to a wide range of loads, from low-level gravitational forces to high-level impacts. A variety of types and magnitudes of mechanical stimuli have been shown to influence human bone cell metabolism in vitro, including fluid shear, tensile and compressive strain, altered gravity and vibration. Therefore, the current article aims to synthesize in vitro data regarding the cellular mechanisms underlying the response of human bone cells to mechanical loading. Current data demonstrate commonalities in response to different types of mechanical stimuli on the one hand, along with differential activation of intracellular signalling on the other. A major unanswered question is, how do bone cells sense and distinguish between different types of load? The studies included in the present article suggest that the type and magnitude of loading may be discriminated by overlapping mechanosensory mechanisms including (i) ion channels; (ii) integrins; (iii) G-proteins; and (iv) the cytoskeleton. The downstream signalling pathways identified to date appear to overlap with known growth factor and hormone signals, providing a mechanism of interaction between systemic influences and the local mechanical environment. Finally, the data suggest that exercise should emphasize the amount of load rather than the number of repetitions.

Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  • Alexander Scott
    • 1
    • 2
  • Karim M. Khan
    • 2
    • 3
  • Vincent Duronio
    • 1
  • David A. Hart
    • 4
  1. 1.Faculty of MedicineUniversity of British ColumbiaVancouverCanada
  2. 2.Centre for Hip Health and Musculoskeletal ResearchVancouver Coastal Health Research InstituteVancouverCanada
  3. 3.Department of Family PracticeSchool of Human Kinetics, University of British ColumbiaVancouverCanada
  4. 4.McCaig Institute for Bone and Joint HealthFaculty of Medicine, University of CalgaryCalgaryCanada