Drugs

, Volume 68, Issue 3, pp 373–381

Amlodipine/Valsartan

Fixed-Dose Combination in Hypertension

Authors

    • Wolters Kluwer Health ¦ Adis
    • Wolters Kluwer Health
  • Dean M. Robinson
    • Wolters Kluwer Health ¦ Adis
    • Wolters Kluwer Health
Adis Drug Profile

DOI: 10.2165/00003495-200868030-00008

Cite this article as:
Plosker, G.L. & Robinson, D.M. Drugs (2008) 68: 373. doi:10.2165/00003495-200868030-00008

Abstract

  • ▴ Amlodipine, a dihydropyridine calcium channel blocker, and valsartan, an angiotensin II receptor blocker, are established antihypertensive agents. Fixed-dose combinations of amlodipine/valsartan are available in several European countries and in the US. Individual dose titration with amlodipine and valsartan is generally recommended before changing to the fixed-dose combination.

  • ▴ Amlodipine/valsartan, at approved dosage regimens, achieved significantly greater reductions in mean sitting diastolic and systolic blood pressure (BP) than amlodipine or valsartan monotherapy, or placebo in two randomized, double-blind, factorial trials in patients with mild to moderate hypertension.

  • ▴ Approximately 80–90% of patients receiving approved dosages of amlodipine/valsartan achieved a response, defined as a mean sitting diastolic BP <90 mmHg or a ≥10 mmHg reduction from baseline.

  • ▴ Subgroup analyses of data from the two trials showed that the antihypertensive efficacy of amlodipine/valsartan in the elderly, Black patients and those with stage 2 hypertension was consistent with that observed in the overall study population.

  • ▴ Marked reductions in BP were also observed in patients whose BP was previously uncontrolled on monotherapy (with various antihypertensives) who were switched (without washout) to amlodipine/valsartan in a phase IIIb-IV study.

  • ▴ Amlodipine/valsartan was generally well tolerated in clinical trials. In particular, the incidence of peripheral oedema was significantly lower in patients receiving amlodipine/valsartan than in those treated with amlodipine monotherapy.

Copyright information

© Adis Data Information BV 2008