Drugs

, Volume 67, Issue 2, pp 237–255

The Clinical Applications of Fluorouracil in Ophthalmic Practice

  • Lekha M. Abraham
  • Dinesh Selva
  • Robert Casson
  • Igal Leibovitch
Review Article

DOI: 10.2165/00003495-200767020-00005

Cite this article as:
Abraham, L.M., Selva, D., Casson, R. et al. Drugs (2007) 67: 237. doi:10.2165/00003495-200767020-00005

Abstract

Fluorouracil (5-fluorouracil, 5-FU) is a pyrimidine analogue that was originally known for its widespread use as an anticancer drug. The ability of 5-FU to reduce fibroblastic proliferation and subsequent scarring has made it an important adjunct in ocular and periorbital surgeries. It is used in primary glaucoma filtering surgeries and in reviving failing filtering blebs, in dacryocystorhinostomy, pterygium surgery, and in vitreoretinal surgery to prevent proliferative vitreoretinopathy. In addition, 5-FU is also gaining recognition in the treatment and surgical management of ocular surface malignancies like ocular surface squamous neoplasia; however, the specific action of the drug on highly proliferating cells limits its use in primary acquired melanosis of the conjunctiva. When applied topically, this drug has a low rate of sight-threatening adverse effects, is inexpensive, and is easy to administer, making it an important tool in enhancing the success rate in ophthalmic surgery and in reducing the recurrence of ocular surface neoplasia.

Copyright information

© Adis Data Information BV 2007

Authors and Affiliations

  • Lekha M. Abraham
    • 1
  • Dinesh Selva
    • 2
    • 3
  • Robert Casson
    • 1
    • 3
  • Igal Leibovitch
    • 4
  1. 1.Glaucoma Services, South Australian Institute of Ophthalmology, Royal Adelaide HospitalUniversity of AdelaideAdelaideAustralia
  2. 2.Oculoplastics and Orbital Unit, South Australian Institute of Ophthalmology, Royal Adelaide HospitalUniversity of AdelaideAdelaideAustralia
  3. 3.Departments of Medicine and SurgeryUniversity of AdelaideAdelaideAustralia
  4. 4.Oculoplastics and Orbital Division, Department of Ophthalmology, Tel-Aviv Medical CenterTel-Aviv UniversityTel-AvivIsrael
  5. 5.Department of Ophthalmology and Visual SciencesRoyal Adelaide Hospital, North TerraceAdelaideAustralia