, Volume 66, Issue 6, pp 731–741

Shift in the Epidemiology of Pertussis Infection

An Indication for Pertussis Vaccine Boosters for Adults?
Current Opinion

DOI: 10.2165/00003495-200666060-00001

Cite this article as:
Yeh, S.H. & Mink, C.M. Drugs (2006) 66: 731. doi:10.2165/00003495-200666060-00001


Pertussis vaccination of young children has been effective in reducing the overall disease burden due to Bordetella pertussis in many countries. However, the disease has not been eliminated, although humans are the only known host of this pathogen. In fact, in some countries, the number of reported cases has increased dramatically from their nadir and epidemics routinely occur. In areas where >80% of children <2 years of age have been vaccinated, the burden of disease has shifted from elementary school-aged children (who are presumably protected by vaccination) to young infants (<6 months of age) and individuals >11 years of age. With the recent availability of acellular pertussis vaccines for older children to adults, consideration of a change in current vaccination policy is necessary in order to provide better disease control.

Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  1. 1.UCLA Center for Vaccine Research at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterTorranceUSA
  2. 2.Miller Children’s HospitalLong BeachUSA
  3. 3.Harbor-UCLA Medical Center/David Geffen School of Medicine at UCLATorranceUSA
  4. 4.Center for Vaccine ResearchTorranceUSA