, Volume 62, Issue 14, pp 2007–2012

The Role of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists in the Management of Diabetic Complications

Leading Article

DOI: 10.2165/00003495-200262140-00001

Cite this article as:
Podar, T. & Tuomilehto, J. Drugs (2002) 62: 2007. doi:10.2165/00003495-200262140-00001


Evidence suggests that ACE inhibitors can be advantageous for prevention and halting progression of both micro- and macrovascular complications in patients with diabetes mellitus. ACE inhibitors are useful antihypertensive agents in both type 1 and type 2 diabetes; however, ACE inhibitor therapy often needs to be supplemented with calcium channel antagonists, β-blockers or diuretics to achieve good blood pressure control. ACE inhibitors are also indicated in non- hypertensive patients with type 1 and type 2 diabetes who have micro- or macroalbuminuria. The effect of ACE inhibitors in halting the development and progression of retinopathy and, potentially, neuropathy needs further proof in large-scale studies. More recently, angiotensin II receptor antagonists are emerging as drugs with the potential to be successfully included in the management of diabetic complications, especially when ACE inhibitors are not suitable because of adverse effects.

Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Department of EndocrinologyTartu University ClinicsTartuEstonia
  2. 2.Department of Public HealthUniversity of HelsinkiHelsinkiFinland
  3. 3.Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health PromotionNational Public Health InstituteHelsinkiFinland