Drugs

, Volume 59, Issue 1, pp 17–31

Advances in Non-Nicotine Pharmacotherapy for Smoking Cessation

  • Lirio S. Covey
  • Maria A. Sullivan
  • J. Andrew Johnston
  • Alexander H. Glassman
  • Mark D. Robinson
  • David P. Adams
Review Article

DOI: 10.2165/00003495-200059010-00003

Cite this article as:
Covey, L.S., Sullivan, M.A., Johnston, J.A. et al. Drugs (2000) 59: 17. doi:10.2165/00003495-200059010-00003

Abstract

Progress in understanding the pharmacological nature of tobacco addiction, along with the modest success rates achieved by the nicotine replacement therapies, has provided the major impetus for the development of non-nicotine drugs as smoking cessation aids. This article reviews evidence from controlled trials of several non-nicotine medications for the treatment of nicotine dependence.

Clonidine was the first non-nicotine medication to show efficacy for smoking cessation in multiple studies, but its effect was found to be limited at best. Positive results across several trials have been consistently demonstrated for amfebutamone (bupropion). Encouraging results have also been observed for nortriptyline and moclobemide. Studies of combined treatments using non-nicotine medications (amfebutamone, mecamylamine, oral dextrose) with nicotine replacement therapy suggest increased efficacy relative to treatments using one or the other treatment strategy alone.

Thus, available evidence indicates that non-nicotine drug treatments offer a promising panoply of therapeutic strategies for the addicted smoker.

Copyright information

© Adis International Limited 2000

Authors and Affiliations

  • Lirio S. Covey
    • 1
    • 2
  • Maria A. Sullivan
    • 1
    • 2
  • J. Andrew Johnston
    • 3
  • Alexander H. Glassman
    • 1
    • 2
  • Mark D. Robinson
    • 4
  • David P. Adams
    • 5
  1. 1.New York State Psychiatric InstituteNew YorkUSA
  2. 2.Department of Psychiatry, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Glaxo-Wellcome Inc.Research Triangle ParkUSA
  4. 4.Cabarrus Family Medicine Residency ProgramConcordUSA
  5. 5.Department of Family Medicine and Public Health, James Quillen School of MedicineEast Tennessee State UniversityJohnson CityUSA