, Volume 54, Issue 1, pp 89–101


  • Caroline M. Spencer
  • Anthony Markham
Adis New Drug Profile

DOI: 10.2165/00003495-199754010-00010

Cite this article as:
Spencer, C.M. & Markham, A. Drugs (1997) 54: 89. doi:10.2165/00003495-199754010-00010


  • ▴ Troglitazone decreases insulin resistance (improves insulin sensitivity), which results in reduced plasma glucose and insulin levels in patients with non-insulin-dependent diabetes mellitus (NIDDM).

  • ▴ Risk factors for cardiovascular disease such as elevated proinsulin and triglyceride levels are also reduced by troglitazone.

  • ▴ In clinical trials, troglitazone 200 to 800mg daily (alone or in combination with other oral antidiabetic agents or insulin) reduced plasma or serum glucose levels and glycosylated haemoglobin compared with both baseline and placebo in patients with NIDDM refractory to other oral antidiabetic agents (usually sulphonylureas).

  • ▴ Troglitazone was generally well tolerated in clinical trials. In patients in the US, the incidence of adverse events in troglitazone recipients was similar to that in placebo recipients.

Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • Caroline M. Spencer
    • 1
  • Anthony Markham
    • 1
  1. 1.Adis International LimitedMairangi Bay, Auckland 10New Zealand