Drugs

, Volume 46, Supplement 1, pp 115–120

Efficacy and Tolerability of Nimesulide in Asthmatic Patients Intolerant to Aspirin

  • S. Bianco
  • M. Robuschi
  • G. Petrigni
  • M. Scuri
  • M. G. Pieroni
  • R. M. Refini
  • A. Vaghi
  • P. S. Sestini
Article

DOI: 10.2165/00003495-199300461-00024

Cite this article as:
Bianco, S., Robuschi, M., Petrigni, G. et al. Drugs (1993) 46(Suppl 1): 115. doi:10.2165/00003495-199300461-00024

Summary

Inflammation of the airways accompanied by eosinophil infiltration appears to play a fundamental role in the pathogenesis of bronchial asthma. Therefore, anti-inflammatory agents (at present corticosteroids, cromoglycate and nedocromil) are the first-line treatment for this condition. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid) and indomethacin, however, have never been used in this setting, mainly for fear of adverse effects (e.g. severe obstructive reactions); these can occur, in a consistent number of patients as a consequence (according to the most widely accepted theory) of inhibition of prostaglandin synthesis. In a double-blind crossover placebo-controlled study involving 20 aspirin-sensitive patients with asthma, we found that oral nimesulide 100mg was well tolerated both clinically and functionally (no significant changes in forced expiratory volume in 1 second and specific airway resistance after drug intake). In a more recent study, we observed a mild obstructive reaction (easily controlled with inhaled bronchodilators) after oral administration of nimesulide 400mg to 3 patients who had previously tolerated a 100mg dose. On the basis of clinical experience, nimesulide (unlike most other NSAIDs) in the recommended doses appears to be well tolerated in aspirin-sensitive asthmatic patients. Furthermore, this distinctive anti-inflammatory agent might provide a novel approach to the treatment of bronchial asthma.

Copyright information

© ADIS International Limited 1993

Authors and Affiliations

  • S. Bianco
    • 1
  • M. Robuschi
    • 2
  • G. Petrigni
    • 2
  • M. Scuri
    • 2
  • M. G. Pieroni
    • 3
  • R. M. Refini
    • 3
  • A. Vaghi
    • 4
  • P. S. Sestini
    • 3
  1. 1.Institute of Cardiovascular and Respiratory DiseasesUniversity of MilanMilanItaly
  2. 2.Institute of Respiratory DiseasesUniversity of MilanMilanItaly
  3. 3.Institute of Respiratory DiseasesUniversity of SienaSienaItaly
  4. 4.Pneumological DivisionHospital of GarbagnateGarbagnateItaly