Drugs

, Volume 43, Supplement 3, pp 27–32

Compassionate Use of a 5-HT3-Receptor Antagonist, Tropisetron, in Patients Refractory to Standard Antiemetic Treatment

  • H. Bleiberg
  • S. Van Belle
  • R. Paridaens
  • G. De Wasch
  • L. Y. Dirix
  • M. Tjean
Article

DOI: 10.2165/00003495-199200433-00007

Cite this article as:
Bleiberg, H., Van Belle, S., Paridaens, R. et al. Drugs (1992) 43: 27. doi:10.2165/00003495-199200433-00007

Summary

The efficacy of tropisetron in the prevention of nausea and vomiting induced by chemotherapy of varying emetogenic potential was evaluated in 545 patients with a variety of malignancies who had either proved refractory to antiemetic treatment during previous chemotherapy courses or who were considered to be at high risk of nausea and vomiting. Tropisetron 5 or 10mg was administered intravenously just before chemotherapy, with the possibility of additional oral or intravenous doses on the day before chemotherapy and on 1 or more subsequent days.

On day 1 of the first course of chemotherapy, a complete response (no nausea and no vomiting) was achieved in 62% of patients and a partial response (1 to 4 vomits and/or episodes of nausea) in 29%. Among the 325 patients who received a second course of chemotherapy, more than 80% of those with a complete response on day 1 of course 1 also had a complete response on day 1 of course 2; 37% and 26%, respectively, of patients with a partial response or failure (1 or more vomits and/or episodes of nausea) on day 1 of course 1 then had a complete response on day 1 of course 2.

Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • H. Bleiberg
    • 1
  • S. Van Belle
    • 2
  • R. Paridaens
    • 3
  • G. De Wasch
    • 4
  • L. Y. Dirix
    • 5
  • M. Tjean
    • 6
  1. 1.Institut BordetBrusselsBelgium
  2. 2.University Hospital of the VUBBrusselsBelgium
  3. 3.CHU Sart TilmanLiègeBelgium
  4. 4.H ServysziekenhuisOostendeBelgium
  5. 5.Antwerp University HospitalAntwerpBelgium
  6. 6.Hôpital du Bois de l’AbbayeSeraingBelgium
  7. 7.Unitè de GastroenterologieInstitut Jules BordetBruxellesBelgium