Practical Therapeutics

Drugs

, Volume 40, Issue 4, pp 531-542

First online:

Current Concepts in the Treatment of Immune Thrombocytopenia

  • Theodore E. WarkentinAffiliated withDepartment of Pathology, McMaster University Medical CentreMcMaster University Medical CentreCanadian Red Cross Blood Transfusion Service, Hamilton Centre
  • , John G. KeltonAffiliated withDepartment of Pathology, McMaster University Medical CentreMcMaster University Medical CentreCanadian Red Cross Blood Transfusion Service, Hamilton Centre

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Summary

Platelet destruction by antibodies is a common cause, of thrombocytopenia. In this review, various treatments for immune thrombocytopenia are discussed, with emphasis on corticosteroids, splenectomy, danazol, high-dose immunoglobulin G, anti-Rhesus globulin, colchicine and cytotoxic, immuftosuppressive agents such as cyclophosphamide and azathioprine. An approach to the treatment of adult idiopathic thrombocytopenic purpura (ITP) is reviewed in detail and the treatments for several other immune thrombocytopenic disorders are summarised.