Clinical Pharmacokinetics

, Volume 10, Issue 3, pp 279–284

Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery

  • Dina Battino
  • S. Binelli
  • L. Bossi
  • R. Canger
  • D. Croci
  • C. Cusi
  • M. De Giambattista
  • G. Avanzini
Original Research Articles

DOI: 10.2165/00003088-198510030-00007

Cite this article as:
Battino, D., Binelli, S., Bossi, L. et al. Clin Pharmacokinet (1985) 10: 279. doi:10.2165/00003088-198510030-00007
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Summary

Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite, carbamazepine 10,11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 52. After the end of the second trimester, there were no variations in plasma carbamazepine 10,11-epoxide concentrations and carbamazepine 10.11-epoxide: carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.

Copyright information

© ADIS Press Limited 1985

Authors and Affiliations

  • Dina Battino
    • 1
  • S. Binelli
    • 1
  • L. Bossi
    • 2
  • R. Canger
    • 3
  • D. Croci
    • 1
  • C. Cusi
    • 1
  • M. De Giambattista
    • 4
  • G. Avanzini
    • 1
  1. 1.Neurological Institute ‘C. Besta’MilanItaly
  2. 2.Department of Clinical ResearchLERSFrance
  3. 3.First Neurological ClinicUniversity of MilanMilanItaly
  4. 4.First Obstetrics ClinicUniversity of MilanMilanItaly
  5. 5.Istituto Neurologico C. BestaMilanoItaly