Drugs & Aging

, Volume 22, Supplement 1, pp 1–26

Guidelines for the Treatment of Alzheimer’s Disease from the Italian Association of Psychogeriatrics

  • Carlo Caltagirone
  • Angelo Bianchetti
  • Monica Di Luca
  • Patrizia Mecocci
  • Alessandro Padovani
  • Elvezio Pirfo
  • Pierluigi Scapicchio
  • Umberto Senin
  • Marco Trabucchi
  • Massimo Musicco
Review Article

DOI: 10.2165/00002512-200522001-00002

Cite this article as:
Caltagirone, C., Bianchetti, A., Di Luca, M. et al. Drugs & Aging (2005) 22(Suppl 1): 1. doi:10.2165/00002512-200522001-00002

Abstract

A committee of experts from the Italian Association of Psychogeriatrics compiled the following report, which was then approved by a Steering Committee (comprising 20 specialists in neurology, psychiatry or geriatrics) from the Association and by two Alzheimer associations representing patients and families: the Italian Association for Alzheimer’s Disease and the Italian Federation for Alzheimer’s Disease. The report is based on a comprehensive review of the scientific literature on the treatment of Alzheimer’s disease, discusses methodological aspects of dementia management, and details the limitations of current therapies.

These guidelines are, in general, consistent with the principles of evidence-based medicine; however, for some controversial or poorly investigated issues, the guidelines integrate scientific evidence with experience and opinions from experts working in the clinical setting. In particular, the clinical experience of experts has been used to define recommendations for starting and interrupting pharmacotherapy, and to critically review evidence about the efficacy of non-pharmacological interventions.

The principal pharmacotherapeutic interventions covered in the guidelines are acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and memantine. The main non-pharmacological interventions reviewed are memory training, reality orientation therapy, and combined non-pharmacological interventions. Other issues covered are opportunities for Alzheimer’s disease prevention, various modalities of care, and the treatment of comorbidities.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  • Carlo Caltagirone
    • 1
  • Angelo Bianchetti
    • 2
  • Monica Di Luca
    • 3
  • Patrizia Mecocci
    • 4
  • Alessandro Padovani
    • 5
  • Elvezio Pirfo
    • 6
  • Pierluigi Scapicchio
    • 7
  • Umberto Senin
    • 4
  • Marco Trabucchi
    • 8
    • 10
  • Massimo Musicco
    • 9
  1. 1.Fondazione IRCCS, Santa LuciaUniversità Tor VergataRomeItaly
  2. 2.Geriatric Research Group and Department of Internal Medicine‘Istituto Clinico S. Anna’BresciaItaly
  3. 3.Institute of Pharmacological Sciences, Center of Excellence for Neurodegenerative DisordersUniversity of MilanItaly
  4. 4.Institute of Gerontology and Geriatrics, Department of Clinical and Experimental MedicineUniversity of PerugiaItaly
  5. 5.Department of NeurologyUniversity of BresciaItaly
  6. 6.Department of Mental Health‘G. Maccacaro’TurinItaly
  7. 7.Catholic University of the Sacred HeartRomeItaly
  8. 8.‘Tor Vergata’ UniversityRomeItaly
  9. 9.Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche Segrate (Mi)Fondazione IRCCSSanta Lucia, RomeItaly
  10. 10.Geriatric Research GroupBresciaItaly
  11. 11.Fondazione Santa LuciaRomaItaly

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