Drugs & Aging

, Volume 21, Issue 11, pp 711–730

The Impact of Fragility Fracture on Health-Related Quality of Life

The Importance of Antifracture Therapy


  • Ted Xenodemetropoulos
    • St Joseph’s HealthcareMcMaster University
  • Shawn Davison
    • St Joseph’s HealthcareMcMaster University
  • George Ioannidis
    • St Joseph’s HealthcareMcMaster University
    • St Joseph’s HealthcareMcMaster University
Review Article

DOI: 10.2165/00002512-200421110-00002

Cite this article as:
Xenodemetropoulos, T., Davison, S., Ioannidis, G. et al. Drugs Aging (2004) 21: 711. doi:10.2165/00002512-200421110-00002


Both general and specific health status instruments can be utilised in evaluating health-related quality of life (HR-QOL) deficits resulting from osteoporotic fractures. Osteoporotic hip, vertebral and wrist fractures significantly decrease HR-QOL in most HR-QOL domains investigated. The presence of multiple vertebral fractures leads to larger decrements in HR-QOL. More research needs to be completed with these HR-QOL tools to better assess the true burden of osteoporotic fractures, particularly in the case of hip fractures, as the burden is surely being underestimated without recognition of HR-QOL. Only when the burden of fragility fractures is understood, inclusive of HR-QOL, will the value of proven antifracture prevention and treatment therapies be appreciated. Information collected by HR-QOL instruments may provide new insight as to how to improve quality of life for patients with fractures and how to properly allocate healthcare spending.

Copyright information

© Adis Data Information BV 2004