Abstract
Fistulas are a frequent and serious complication of Crohn's disease. Most of the literature has been focused on perianal fistulas, which are by far the most frequent. The effectiveness of treatment with infliximab in fistulizing Crohn's disease was demonstrated in the ACCENT II trial. In that study, however, all patients had external fistulas, and the majority of those were perianal fistulas. The response to fistula treatment in other locations was not evaluated.
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References
Schwartz D, Loftus E, Tremaine W, et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 2002; 122: 875–80
Keighley M, Alan R. Current status and influence of operation on perianal Crohn's disease. Int J Colorectal Dis 1986; 1: 104–7
Hellers G, Bergstrand O, Ewerths S et al. Occurrence and outcome after primary treatment of anal fistulas in Crohn's disease. Gut 1980; 21: 525–7
Broe P, Bayless T, Cameron J. Crohn's disease: are enteroenteral fistulas an indication for surgery? Surgery 1982 Mar; 91(3): 249–53
Caprilli R, Gassull M, Escher J, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: special situations. Gut 2006; 55: 36–58
Chambrun G, Peyrin-Biroulet L, Lémann M, et al. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol 2010; 7: 15–29
Sands B, Anderson F, Bernstein C, et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004; 350: 876–85
Sands B, Blank M, Patel K, et al. Long term treatment of rectovaginal fistula in Crohn's disease: response to infliximab in ACCENT II Study. Clin Gastroenterol Hepatol 2004; 2: 912–20
Parsi M, Lashner B, Achkar J, et al. Type of fistula determines response to infliximab in patients with fistulous Crohn's disease. Am J Gastroenterol 2004; 99: 445–9
Kim S, Yang K, Kim E, et al. Efficacy of infliximab in the treatment of Korean patients with Crohn's disease. Korean J Gastroenterol 2009; 54: 108–16
Acknowledgments
The authors would like to thank GEDII (Portuguese Group for the Study of Inflammatory Bowel Disease) for reviewing the case report. Dr Nunes received honoraria for the submission of the case report, which was funded by Schering-Plough/MSD Portugal. The other authors declare no potential conflicts of interest relevant to this case report.
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Nunes, J., Santos, P.M. & Tavares, L. Complete Resolution of Enterocolic Fistulas with Infliximab. BioDrugs 24 (Suppl 1), 28–30 (2010). https://doi.org/10.2165/11586260-000000000-00000
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DOI: https://doi.org/10.2165/11586260-000000000-00000