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Angiotensin II Signalling in Bartter’s and Gitelman’s Syndromes

A Negative Human Model of Hypertension

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Abstract

In extensive studies of patients with Bartter’s and Gitelman’s syndromes, we have shown biochemical abnormalities in angiotensin II (Ang II) short- and long-term cell signalling, which depict a mirror image of those found in hypertension. The information obtained from the study of this human model of altered vascular tone regulation shows that it can be used to gather more general data and/or confirm mechanistic details of the cellular and biochemical events involved in the pathophysiology of vascular tone control, and to shed light on the multiplicity of the Ang II signalling-related mechanisms responsible for the pathophysiology of hypertension and its long-term complications, such as cardiovascular remodelling and atherogenesis.

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Acknowledgements

Studies included in this review have been supported in part by a grant from the Italian Society of Hypertension (SIIA) and by a grant from Regione Veneto to L.A. Calò and in part by a grant from MURST to A. Semplicini.

The authors have no conflicts of interest directly related to the contents of this review.

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  1. Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy

    Lorenzo A. Calò, Achille C. Pessina & Andrea Semplicini

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  1. Lorenzo A. Calò
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  2. Achille C. Pessina
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  3. Andrea Semplicini
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Correspondence to Lorenzo A. Calò.

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Calò, L.A., Pessina, A.C. & Semplicini, A. Angiotensin II Signalling in Bartter’s and Gitelman’s Syndromes. High Blood Press Cardiovasc Prev 12, 17–26 (2005). https://doi.org/10.2165/00151642-200512010-00004

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