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Therapeutic Potential of Adult Progenitor Cells in the Management of Chronic Myocardial Ischemia

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Abstract

Refractory angina as a result of chronic myocardial ischemia is a common and disabling condition. Adult progenitor cells have emerged as a potential revolutionary treatment for cardiovascular disease. Locally administered adult progenitor cells with particular vasculogenic potential may offer treatment hope for those with chronic ischemia; however, the optimal cell type, dose, delivery mode, and target patient population has not been defined. Preclinical cell therapy studies have shown safety and efficacy sufficient to warrant human trials. Early, small-scale human trials exploring various cell types and delivery modes have shown that most approaches are safe, with modest early efficacy. This overview discusses the rationale and early results for ongoing larger cardiovascular disease trials, with a special emphasis on refractory angina and chronic myocardial ischemia.

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Acknowledgments

The author has no disclosures. The author is a site investigator for the ACT34-CMI multicenter clinical trial and receives no funds from the sponsor (Baxter Healthcare Inc., Deerfield, IL, USA) beyond study-related expenses. Special thanks to Ms Anjali Tannan for assistance with the graphical design of figures.

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  1. Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, H6/321 Clinical Sciences Center, 600 Highland Ave, Madison, WI, 53792-3248, USA

    Amish N. Raval

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Raval, A.N. Therapeutic Potential of Adult Progenitor Cells in the Management of Chronic Myocardial Ischemia. Am J Cardiovasc Drugs 8, 315–326 (2008). https://doi.org/10.2165/00129784-200808050-00004

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