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Enhancement of mRNA expression of survivin and human beta-defensin-3 in lesions of psoriasis vulgaris

  • Investigative Report
  • Published:
European Journal of Dermatology Aims and scope

Abstract

Background

Suppression of apoptosis is one of the pathogenetic mechanisms for psoriasis vulgaris (PV). Survivin has the function of regulating cell division and inhibiting apoptosis. Patients with PV have an increased resistance to cutaneous infections. Human β-defensin-3 (hBD-3) is a kind of antimicrobial peptide with antimicrobial activities.

Objectives

To assess and compare the transcript levels of survivin and hBD-3 in pairwise skin from PV.

Materials & Methods

A total of 20 patients, 10 with mild PV and 10 with severe PV, and 10 healthy control donors were recruited in the study. Real-time PCR was conducted to determine survivin and hBD-3 mRNA expression in skin lesions and normal-appearing skin of PV patients, and normal skin of healthy controls.

Results

Compared with normal control skin, the survivin mRNA expression of normal-appearing skin in the mild PV group, lesions of the mild PV group and the severe PV group were significantly elevated (P<0.05). hBD-3 mRNA expression was statistically increased in both normal-appearing skin and in lesions in mild and severe PV groups, in contrast to normal skin (P<0.001). Significant differences of hBD-3 mRNA were also found between lesions and non-lesional skin in the mild PV group and severe PV group (P<0.05). Survivin mRNA levels were mildly correlated with hBD-3 mRNA levels (r s = 0.398; P<0.05) in skin lesions from 20 PV patients.

Conclusion

Survivin and hBD-3 may be involved in the pathogenesis of psoriasis.

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Author information

Authors and Affiliations

  1. Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

    Fang Wang

  2. Department of Dermatology, Shekou People’s Hospital, Shenzhen, Guangdong, China

    Xia Zhang & Li Zhang

  3. Department of Dermatology, Huashan Hospital, Fudan University, No. 12 Wulumuqizhong Road, Shanghai, 200040, China

    Ping Xia & Zhenghua Zhang

Authors
  1. Fang Wang
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  2. Xia Zhang
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  3. Ping Xia
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  4. Li Zhang
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  5. Zhenghua Zhang
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Corresponding author

Correspondence to Zhenghua Zhang.

Additional information

Fang Wang and Xia Zhang contributed equally to this work.

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Cite this article

Wang, F., Zhang, X., Xia, P. et al. Enhancement of mRNA expression of survivin and human beta-defensin-3 in lesions of psoriasis vulgaris. Eur J Dermatol 26, 28–33 (2016). https://doi.org/10.1684/ejd.2015.2698

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  • DOI: https://doi.org/10.1684/ejd.2015.2698

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