Review

Journal of Zhejiang University SCIENCE B

, Volume 13, Issue 9, pp 663-675

First online:

Molecular biomarkers of colorectal cancer: prognostic and predictive tools for clinical practice

  • Wei-qin JiangAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Fang-fang FuAffiliated withInstitute of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Yang-xia LiAffiliated withInstitute of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Wei-bin WangAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Hao-hao WangAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Hai-ping JiangAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Li-song TengAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University Email author 

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Abstract

Colorectal cancer remains one of the most common types of cancer and leading causes of cancer death worldwide. Although we have made steady progress in chemotherapy and targeted therapy, evidence suggests that the majority of patients undergoing drug therapy experience severe, debilitating, and even lethal adverse drug events which considerably outweigh the benefits. The identification of suitable biomarkers will allow clinicians to deliver the most appropriate drugs to specific patients and spare them ineffective and expensive treatments. Prognostic and predictive biomarkers have been the subjects of many published papers, but few have been widely incorporated into clinical practice. Here, we want to review recent biomarker data related to colorectal cancer, which may have been ready for clinical use.

Key words

Colorectal cancer Biomarker Predictive value Prognostic value Chemotherapy Targeted therapy

CLC number

R735.3