Journal of Zhejiang University SCIENCE B

, Volume 11, Issue 5, pp 315–322

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Authors

  • Eun-Jin Yang
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
  • Ji-Young Moon
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
  • Min-Jin Kim
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
  • Dong Sam Kim
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
  • Chan-Shick Kim
    • Faculty of BiotechnologyCheju National University
  • Wook Jae Lee
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
  • Nam Ho Lee
    • Jeju Seaweed Industry Development AgencyCheju National University
    • Department of ChemistryCheju National University
  • Chang-Gu Hyun
    • Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI)
    • Jeju Seaweed Industry Development AgencyCheju National University
Article

DOI: 10.1631/jzus.B0900364

Cite this article as:
Yang, E., Moon, J., Kim, M. et al. J. Zhejiang Univ. Sci. B (2010) 11: 315. doi:10.1631/jzus.B0900364

Abstract

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough, boils, goiters, stomach ailments, and urinary diseases, and for reducing the incidence of tumors, ulcers, and headaches. Despite the fact that seaweeds are frequently used in the practice of human health, little is known about the role of seaweed in the context of inflammation. This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line (RAW 264.7) under the stimulation of lipopolysaccharide (LPS). Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators. Our results revealed that extracts from five seaweeds, Laurencia okamurae, Grateloupia elliptica, Sargassum thunbergii, Gloiopeltis furcata, and Hizikia fusiformis, were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Based on these results, the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential therapeutic applications in the regulation of the inflammatory response.

Key words

Nitric oxideInterleukin-6 (IL-6)Prostaglandin E2 (PGE2)Tumor necrosis factor-α (TNF-α)SeaweedsPro-inflammatory mediators

CLC number

Q94

Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2010