Journal of Zhejiang University SCIENCE B

, Volume 11, Issue 10, pp 754–761

A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients

  • Xiao-hong Pan
  • Ying-xue Chen
  • Mei-xiang Xiang
  • Geng Xu
  • Jian-an Wang
Article

DOI: 10.1631/jzus.B0900302

Cite this article as:
Pan, X., Chen, Y., Xiang, M. et al. J. Zhejiang Univ. Sci. B (2010) 11: 754. doi:10.1631/jzus.B0900302
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Abstract

A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent (PES) in ST-segment elevation myocardial infarction (STEMI) patients. A systematic literature search was conducted to identify all randomized clinical trials in mortality, recurrent myocardial infarction (rMI), repeat revascularization (RR), and stent thrombosis (ST). A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent (BMS). The pooled repeat revascularization rate was 5.7% in PES group, significantly lower than 10.0% in BMS group with an odds ratio (OR) of 0.56, 95% confidence interval (CI) [0.44, 0.72] (P<0.00001). No significant difference was found between PES and BMS groups in mortality at one year after the indexing procedure (3.9% vs. 5.1%, OR 0.88, 95% CI [0.63, 1.21], P=0.42). Similarly, rMI rate did not differ significantly between the two groups (3.4% vs. 4.1%, OR 0.80, 95% CI [0.56, 1.13], P=0.21). PES was also associated with the comparable pooled rate of definite stent thrombosis with BMS (2.3% vs. 2.4%, OR 0.81, 95% CI [0.52, 1.26], P=0.35). The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety.

Key words

Myocardial infarction Paclitaxel-eluting stent Bare-metal stent Meta-analysis 

CLC number

R54 

Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Xiao-hong Pan
    • 1
  • Ying-xue Chen
    • 1
  • Mei-xiang Xiang
    • 1
  • Geng Xu
    • 1
  • Jian-an Wang
    • 1
  1. 1.Department of Cardiology, the Second Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina

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