Journal of Zhejiang University SCIENCE B

, 10:147

Anti-allergic effects of ethanol extracts from brown seaweeds

Authors

  • Haider Samee
    • Food Safety Laboratory, College of Food Science and EngineeringOcean University of China
    • Food and Marine Resources Research CentrePakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex
  • Zhen-xing Li
    • Food Safety Laboratory, College of Food Science and EngineeringOcean University of China
    • Food Safety Laboratory, College of Food Science and EngineeringOcean University of China
  • Jamil Khalid
    • Food and Marine Resources Research CentrePakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex
  • Yong-chao Guo
    • Food Safety Laboratory, College of Food Science and EngineeringOcean University of China
Article

DOI: 10.1631/jzus.B0820185

Cite this article as:
Samee, H., Li, Z., Lin, H. et al. J. Zhejiang Univ. Sci. B (2009) 10: 147. doi:10.1631/jzus.B0820185

Abstract

Ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities. They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan, and Sargassum graminifolium turn (SG), Sargassum thunbergii (STH), and Laminaria japonica (LJ) from China. The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of phlorotannin, an inhibitor against hyaluronidase. Total phlorotannins contained in the crude extracts were measured as 1.71% (SG), 0.74% (STH), 0.97% (LJ), 3.30% (SC), and 5.06% (ST). The 50% inhibitory concentrations (IC50) of Pakistani SC and ST were 109.5 and 21 μg/ml, respectively, lower than those of Chinese SG, STH, and LJ (134, 269, and 148 μg/ml, respectively). An antiallergic drug, disodium cromoglycate (DSCG), had an IC50=39 μg/ml, and a natural inhibitor of hyaluronidase, catechin, had an IC50=20 μg/ml. The IC50 of ST extract was found similar to that of catechin (21 vs 20 μg/ml) and lower than that of DSCG (21 vs 39 μg/ml). This suggests that ST is a potent inhibitor of hyaluronidase, indicating a promising future development of natural antiallergic medicines or functional foods.

Key words

Anti-allergic activityBrown seaweedEthanol extractsHyaluronidasePhlorotannin

CLC number

TS254

Copyright information

© Zhejiang University and Springer-Verlag GmbH 2009