Review

Journal of Zhejiang University SCIENCE B

, Volume 9, Issue 2, pp 85-89

First online:

BRCA1/2 associated hereditary breast cancer

  • Li-song TengAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University Email author 
  • , Yi ZhengAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University
  • , Hao-hao WangAffiliated withCancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

Key words

BRCA1 BRCA2 Hereditary breast cancer

Document code

A

CLC number

R737.9