Article

Journal of Zhejiang University SCIENCE A

, Volume 8, Issue 2, pp 323-330

A remote control training system for rat navigation in complicated environment

  • Feng Zhou-yan Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University
  • , Chen Wei-dong Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Computer Science and Technology, Zhejiang University Email author 
  • , Ye Xue-song Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University
  • , Zhang Shao-min Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University
  • , Zheng Xiao-jing Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University
  • , Wang Peng Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University
  • , Jiang Jun Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Computer Science and Technology, Zhejiang University
  • , Jin Lin Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Computer Science and Technology, Zhejiang University
  • , Xu Zhi-jian Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Computer Science and Technology, Zhejiang University
    • , Liu Chun-qing Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversitySchool of Medicine, Zhejiang University
    • , Liu Fu-xin Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversitySchool of Medicine, Zhejiang University
    • , Luo Jian-hong Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversitySchool of Medicine, Zhejiang University
    • , Zhuang Yue-ting Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Computer Science and Technology, Zhejiang University Email author 
    • , Zheng Xiao-xiang Affiliated withQiushi Academy for Advanced Studies, Zhejiang UniversityCollege of Biomedical Engineering and Instrument Science, Zhejiang University Email author 

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Abstract

A remote control system has been developed to deliver stimuli into the rat brain through a wireless micro-stimulator for animal behavior training. The system consists of the following main components: an integrated PC control program, a transmitter and a receiver based on Bluetooth (BT) modules, a stimulator controlled by C8051 microprocessor, as well as an operant chamber and an eight-arm radial maze. The micro-stimulator is featured with its changeable amplitude of pulse output for both constant-voltage and constant-current mode, which provides an easy way to set the proper suitable stimulation intensity for different training. The system has been used in behavior experiments for monitoring and recording bar-pressing in the operant chamber, contriolling rat roaming in the eight-arm maze, as well as navigating rats through a 3D obstacle route. The results indicated that the system worked stably and that the stimulation was effective for different types of rat behavior controls. In addition, the results showed that stimulation in the whisker barrel region of rat primary somatosensory cortex (SI) acted like a cue. The animals can be trained to take different desired turns upon the association between the SI cue stimulation and the reward stimulation in the medial forebrain bundle (MFB).

Key words

Remote control Brain Navigation Stimulator Reward stimulation Whisker

CLC number

R338 TP8