Journal of Zhejiang University SCIENCE B

, Volume 7, Issue 10, pp 806-816

First online:

Computational prediction of microRNA genes in silkworm genome

  • Tong Chuan-zhou Affiliated withInstitute of Biochemistry, School of Life Science, Zhejiang University
  • , Jin Yong-feng Affiliated withInstitute of Biochemistry, School of Life Science, Zhejiang University Email author 
  • , Zhang Yao-zhou Affiliated withInstitute of Biochemistry, School of Life Sciences, Zhejiang Science and Technology University

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MicroRNAs (miRNAs) constitute a novel, extensive class of small RNAs (∼21 nucleotides), and play important gene-regulation roles during growth and development in various organisms. Here we conducted a homology search to identify homologs of previously validated miRNAs from silkworm genome. We identified 24 potential miRNA genes, and gave each of them a name according to the common criteria. Interestingly, we found that a great number of newly identified miRNAs were conserved in silkworm and Drosophila, and family alignment revealed that miRNA families might possess single nucleotide polymorphisms. miRNA gene clusters and possible functions of complement miRNA pairs are discussed.

Key words

miRNA Silkworm Computational prediction

CLC number