Skip to main content
SpringerLink
Log in

A meta-analysis of association between acne vulgaris and Demodex infestation

  • Published:
Journal of Zhejiang University SCIENCE B Aims and scope Submit manuscript

Abstract

Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants including students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34–3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ayres, S.Jr., 1930. Pityriasis folliculorum (Demodex). Arch. Derm. Syphilol., 21(1):19–24. [doi:10.1001/archderm.1930.01440070027002]

    Article  Google Scholar 

  • Ayres, S.Jr., Ayres, S.III, 1961. Demodectic eruptions (demodicidosis) in the human. Arch. Dermatol., 83(5): 816–827. [doi:10.1001/archderm.1961.01580110104016]

    Article  PubMed  Google Scholar 

  • Baysal, V., Aydemir, M., Yorgancigil, B., Yildirim, M., 1997. The role of Demodexes on etiology and pathogenesis of acne vulgaris. Turkiye Parazitol. Derg., 21:265–268 (in Turkish).

    Google Scholar 

  • Bonnar, E., Eustace, P., Powell, F.C., 1993. The Demodex mites population in rosacea. J. Am. Acad. Dermatol., 28(3):443–448. [doi:10.1016/0190-9622(93)70065-2]

    Article  PubMed  CAS  Google Scholar 

  • Cao, G.L., Huang, Z., Liu, Y.B., 2005. Investigation in infections rate of follicle mite in some medical students in Ganzhou. J. Gannan Med. Coll., 25(5):596–597 (in Chinese).

    Google Scholar 

  • Cao, Y.S., You, Q.X., Wang, L., Lan, H.B., Xu, J., Zhang, X.H., Yang, H., Xiong, Y.J., Tian, X.F., 2009. Facial Demodex infection among college students in Tangshan. Chin. J. Parasitol. Parasit Dis., 27(3):271–273 (in Chinese).

    Google Scholar 

  • Chen, J.F., Chen, Y., Yan, D.D., Guo, X.R., Yang, H.D., Niu, B., Du, F.X., 2006. Investigation of Demodex infection in undergraduates. Acta Baotou Med. Coll., 22(2):135–136 (in Chinese).

    Google Scholar 

  • Chen, L.Q., Long, B., Wan, Q.H., Huang, X.G., Liu, H., He, L.F., Zhou, B.Y., 2008. Investigation of Demodex infection in students of a university. Lab. Med. Clin., 5(20): 1246–1248 (in Chinese).

    Google Scholar 

  • Chen, X.C., Liu, J.H., Su, L.Y., Li, Y.H., 1993. Investigation on the Demodex infection among college students. J. Taishan Med. Coll., 14(4):272–275 (in Chinese).

    Google Scholar 

  • Chen, X.N., Zhao, X.J., Yan, Y., 1996. Study on face infection caused by Demodex folliculorum and epidemic factors in 444 college students. J. Chengde Med. Coll., 13(1):13–15 (in Chinese).

    CAS  Google Scholar 

  • Chen, X.Y., Shen, H.X., Li, X.M., Lin, W.Y., Li, G.P., Ruan, Y.F., Wang, X.Y., Cai, C.T., 2004. The investigation of human follicle mite infection in college students. J. Trop. Med., 4(4):401–403 (in Chinese).

    Google Scholar 

  • Chen, Y.G., Yang, Z.M., Chen, D.F., 1995. Primary investigation of facial Demodex infection. J. Hainan Univ., 13(2):145–147 (in Chinese).

    Google Scholar 

  • Clyti, E., Sayavong, K., Chanthavisouk, K., 2005. Demodecidosis in a patient infected by HIV: successful treatment with ivermectin. Ann. Dermatol. Venereol., 132(5): 459–461 (in French). [doi:10.1016/S0151-9638(05)79308-X]

    Article  PubMed  CAS  Google Scholar 

  • Damian, D., Rogers, M., 2003. Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin. Int. J. Dermatol., 42(9):724–726. [doi:10.1046/j.1365-4362.2003.01916.x]

    Article  PubMed  Google Scholar 

  • Dhingra, K.K., Saroha, V., Gupta, P., Khurana, N., 2009. Demodex-associated dermatologic conditions—a coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. Pathol. Res. Pract., 205(6):423–426. [doi:10.1016/j.prp.2008.11.013]

    Article  PubMed  Google Scholar 

  • Di, B.H., Li, X., Li, C.Y., 2007. Investigation and analysis of Demodex infection in Tianjin undergraduate students. Chin. J. Health Lab. Technol., 17(7):1279, 1313 (in Chinese).

    Google Scholar 

  • Divani, S., Barpakis, K., Kapsalas, D., 2009. Chronic blepharitis caused by Demodex folliculorum mites. Cytopathology, 20(5):343–344. [doi:10.1111/j.1365-2303.2009.00639.x]

    Article  PubMed  CAS  Google Scholar 

  • Dong, H.J., Duncan, L.D., 2006. Cytologic findings in Demodex folliculitis: a case report and review of the literature. Diagn. Cytopathol, 34(3):232–234. [doi:10.1002/dc.20426]

    Article  PubMed  Google Scholar 

  • Du, L.Y., Zhao, L., Chen, X.N., Mi, S.B., 2006. Investigation and analysis of Demodex infection in undergraduate medical students. Chin. J. Health Stat., 23(6):532–533 (in Chinese).

    Google Scholar 

  • Erbagci, Z., Erbagci, I., Erkiliç, S., 2003. High incidence of demodicidosis in eyelid basal cell carcinomas. Int. J. Dermatol., 42(7):567–571. [doi:10.1046/j.1365-4362.2003.01928.x]

    Article  PubMed  Google Scholar 

  • Fang, F., Xiao, X.L., Zeng, Y.W., Ding, S., 2003. The influence of occupation and air-condition on Demodex infection. Guangzhou Med. J., 34(5):59–60 (in Chinese).

    Google Scholar 

  • Forton, F., 2007. Standardized skin surface biopsy: method to estimate the Demodex folliculorum density, not to study the Demodex folliculorum prevalence. J. Eur. Acad. Dermatol. Venereol., 21(9):1301–1302. [doi:10.1111/j.1468-3083.2007.02455.x]

    Article  PubMed  CAS  Google Scholar 

  • Forton, F., Seys, B., 1993. Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br. J. Dermatol., 128(6):650–659. [doi:10.1111/j.1365-2133.1993.tb00261.x]

    Article  PubMed  CAS  Google Scholar 

  • Guo, E.P., Wang, S.L., Wang, Y., Wang, J.Y., 2005. Demodex infection of college students in Yunyang Medical College. Chin. J. Sch. Health., 26(6):469–470 (in Chinese).

    Google Scholar 

  • Han, J., Tao, H.Z., 1988. Epidemiological investigation on human Demodex infection. Guizhou Med. J., 12(4): 234–236.

    Google Scholar 

  • Han, W.B., 1994. Investigation of Demodex infestation in military academy students and analysis of mitecide effectiveness with sulphur soap. Clin. J. Med. Offic., 22(3): 9–10 (in Chinese).

    Google Scholar 

  • He, X., Chen, Y.Z., Wu, S.Y., Zhang, C.F., Wang, Q.H., Pan, L.L., 2009. Investigation of Demodex infection in students of Fujian Medical University. Strait J. Prev. Med., 15(1):39–40 (in Chinese).

    Google Scholar 

  • Hsu, C.K., Hsu, M.M., Lee, J.Y., 2009. Demodicosis: a clinicopathological study. J. Am. Acad. Dermatol., 60(3): 453–462. [doi:10.1016/j.jaad.2008.10.058]

    Article  PubMed  Google Scholar 

  • Hu, S.F., Xia, H., Yang, Y.R., Zhao, Y.X., Liu, J.R., 1995. Investigation of Demodex infection in Bozhou secondery school students. J. Bengbu Med. Coll., 20(1):55 (in Chinese).

    Google Scholar 

  • Ji, Y.L., Zhou, X.Y., Tang, X.Y., Zhang, H.J., Zhao, D.F., Guan, M.S., 2003. Investigation of Demodex infection in medical students. Chin. J. Parasitol. Parasit Dis., 21(6):377 (in Chinese).

    Google Scholar 

  • Jiang, T.C., Li, L.Y., Peng, W., Yang, X.D., 2002. Investigation of Demodex infection in Yichang college students. J. Shanxi Med. Univ., 33(S1):5–6 (in Chinese).

    Google Scholar 

  • Kong, J.L., Shao, C.L., Ren, L.L., Nie, L.H., 2011. Mite infection survey of medical college students. J. Math. Med., 24(1):78 (in Chinese).

    Google Scholar 

  • Li, J.H., 1990. The epidemiology investigation of demodicidosis in Huairen of Guizhou. Guizhou Med. J., 14(5): 314–315 (in Chinese).

    Google Scholar 

  • Li, Z., Wang, B.R., Cheng, Y.B., Ma, C., Zhang, M.R., 1991. Investigation on the infection of Demodex in Xi’an. J. Xi’an Med. Univ., 12(2):165–167 (in Chinese).

    Google Scholar 

  • Liang, D.H., Xin, B., Sun, J.B., Lu, Z.M., 2003. The investigation of Demodex mites infection among 1037 university students of Zhangjiakou medical college. J. Zhangjiakou Med. Coll., 20(2):20–22 (in Chinese).

    Google Scholar 

  • Lin, F.C., 1996. Investigation of facial Demodex infection in students of health school. J. Sch. Health, 17(1):78 (in Chinese).

    Google Scholar 

  • Liu, G.Z., Li, X.C., 2006. Investigation on the infection of Demodex among students in primary and middle school in rural area of Yanzhou city. J. Pathog. Biol., 1(1):s3 (in Chinese).

    Google Scholar 

  • Liu, Y.S., Yang, Y.P., Xie, D., Liu, S.H., Zhao, Q., Miu, H.H., Chen, S.J., Zhu, X.P., 2005. Analysis of Demodex infection of college students. Chin. J. Parasit Dis. Con., 18(5):396 (in Chinese).

    Google Scholar 

  • Moravvej, H., Dehghan-Mangabadi, M., Abbasian, M.R., Meshkat-Razavi, G., 2007. Association of rosacea with demodicosis. Arch. Iran Med., 10(2):199–203.

    PubMed  Google Scholar 

  • Nong, Z.J., 1994. An analysis of the investigation on demodectic infection and epidemics in middle school students and pupils. Acta Med. Sin., 7:21–23 (in Chinese).

    Google Scholar 

  • Nong, Z.J., Nong, L.L., Mo, G., Jiang, L.P., 2011. Demodex infection of medical students and its related factors. Chin. J. Sch. Health, 32(1):84–85 (in Chinese).

    Google Scholar 

  • Okyay, P., Ertabaklar, H., Savk, E., Ertug, S., 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. J. Eur. Acad. Dermatol. Venereol., 20(4):474–476. [doi:10.1111/j.1468-3083.2006.01470.x]

    Article  PubMed  CAS  Google Scholar 

  • Pan, C.W., 1989. A study on the epidemiology of human Demodex in Wenzhou. J. Wenzhou Med. Coll., 19(3): 195–196 (in Chinese).

    Google Scholar 

  • Pan, C.W., Zhang, Z.Y., 1992. Investigation on Demodex infection in 737 facial demodicosis patients. Chin. J. Dermatovenereol., 6(3):156 (in Chinese).

    Google Scholar 

  • Peng, R.Y., Liu, Y.M., Tian, G.P., Bian, T.Y., Zhang, Y.H., 1983. Investigation on the infestation, the pathogenic effect of the mites in Tianjin. Tianjin Med. J., 11(10): 592–594 (in Chinese).

    Google Scholar 

  • Post, C.F., Juhlin, E., 1963. Demodex folliculorum and blepharitis. Arch. Dermatol., 88(3):298–302. [doi:10.1001/archderm.1963.01590210056008]

    Article  PubMed  CAS  Google Scholar 

  • Purcell, S.M., Hayes, T.J., Dixon, S.L., 1986. Pustular folliculitis associated with Demodex folliculorum. J. Am. Acad. Dermatol., 15(5):1159–1162. [doi:10.1016/S0190-9622(86)70287-9]

    Article  PubMed  CAS  Google Scholar 

  • Qin, J., Liu, Y.C., Guo, Y.H., Sheng, Z.Q., 1988. Investigation of Demodex infection among college students. J. Jining Med. Coll., 11(4):31–33 (in Chinese).

    Google Scholar 

  • Qin, X.H., Qin, W.Q., Liu, X.Q., Lu, Z.C., 2005. Investigation of Demodex infection in medical students and relative analysis. Guangxi J. Prev. Med., 11(6):337–339 (in Chinese).

    Google Scholar 

  • Rosenthal, R., 1979. The file-drawer problem and tolerance of null results. Psychol. Bull., 86(3):638–641. [doi:10.1037/ 0033-2909.86.3.638]

    Article  Google Scholar 

  • Ru, X.Y., Chen, X.B., Hu, S.F., Su, L.Y., Liu, J.H., Chen, X.C., 1993. Investigation on human Demodex in the students of primary and middle schools. J. Taishan Med. Coll., 14(2): 114–116 (in Chinese).

    Google Scholar 

  • Shang, J.K., Xu, S.Z., Jiang, G.Y., Ma, Y., Qiao, Z.J., Zhang, Y., 2010. Investigation on Demodex infestation in 1103 health and patients with skin disease. J. Pract. Dermatol., 3(1):13–15 (in Chinese).

    Google Scholar 

  • Song, P., Liu, S.J., Zhao, F.Z., 2009. Investigation of human Demodex infection between 2007 and 2008. China Foreign Med. Treat., 28:118–119 (in Chinese).

    Google Scholar 

  • Sun, X.Q., Zhao, S.Y., Su, J., 1987. Examination of students of a college infected with Demodex folliculorum in Harbin. J. Harbin Med. Univ., 21(5):22–24 (in Chinese).

    Google Scholar 

  • Suo, Z.Q., Shi, Y.M., Yun, D.C., 2001. Investigation of demodicid mites infection among school students in Zhengzhou. Henan J. Prev. Med., 12(6):339–340 (in Chinese).

    Google Scholar 

  • Tao, Y.J., Peng, F.G., Hu, X.H., 2007. Investigation of Demodex infection in 1520 medical students. Pract. Prev. Med., 14(5):1463–1464 (in Chinese).

    Google Scholar 

  • Tu’er, X.A., Qiao, J.Y., Xue, H.B., 1997. Study on pathogenicity and pathogenic factor of human Demodex. Endem. Dis. Bull., 12(2):80–81 (in Chinese).

    Google Scholar 

  • Wang, A.H., Wang, T., 2008. Analysis of the relation between the facial skin diseases and the infection of demodicid mites in teenagers. Mod. Prev. Med., 35(17):3396–3399 (in Chinese).

    Google Scholar 

  • Wang, G.Y., Zhang, Y.S., 2006. Investigation of Demodex infection among medical students. Chin. J. Parasitol. Parasit. Dis., 24(2):156–157 (in Chinese).

    Google Scholar 

  • Wang, H.Y., Wang, X.X., Tu, L.X., 2010. Infection of human Demodex on facial skin of middle and primary students in rural areas of Huaibei. Mod. Prev. Med., 37(9): 1728–1729 (in Chinese).

    Google Scholar 

  • Wang, Y.P., Cui, L.M., Wang, C., Li, F., Qiu, Z.X., 1982. Investigation on the Demodex infestation in Changchun. J. Norman Bethune Univ. Med. Sci., 8(3):79–80 (in Chinese).

    Google Scholar 

  • Xia, H., Hu, S.F., Chen, X.B., 1999. Relationship between vermiform mite infection and facial dermatosis. J. Pract. Parasit. Dis., 7(3):142–143 (in Chinese).

    Google Scholar 

  • Xing, D.R., Shi, J.M., Wu, Z.X., 1988. Further investigation on human Demodex infestation in Xuzhou. Acta Acad. Med. Xuzhou, 8(4):250–252 (in Chinese).

    Google Scholar 

  • Yang, H.N., Che, J., Yang, H.N., Xiao, Q.L., 2006. Study on the association between acne vulgaris and Demodex infection and Cuofuxin liniment treatment. Med. J. Chin. People’s Armed Police Forces, 17(1):55 (in Chinese).

    Google Scholar 

  • Yang, X.H., Duan, X.L., 2001. Investigation of Demodex infection in young students. J. Shanxi Med. Coll. Contin. Educ., 11(2):31–32 (in Chinese).

    Google Scholar 

  • Yang, X.H., Fan, L.N., Sun, X.L., Liu, T.Q., Yang, G.H., Qi, L., 2001. Investigation and analysis of 452 Demodex infection cases. Hebei Med. J., 23(3):215 (in Chinese).

    Google Scholar 

  • Yang, X.H., Wang, P., Deng, S.F., Wang, H., Feng, J.X., Liu, Y., Sun, X.L., 2010. Demodex infection investigation of 432 health noncommissioned officer students. Clin. J. Med. Offic., 38(3):478–479 (in Chinese).

    Google Scholar 

  • Yang, X.H., Deng, S.F., Wang, P., Feng, J.X., Fu, Z.J., Wang, H., Zhao, M.L., 2011. Demodex infection investigation of military health NCO trainees. Chin. J. Clin. Rational Drug Use, 4(7A):163–164 (in Chinese).

    Google Scholar 

  • Yang, X.M., Luo, Y., 2006. Survey of infectious status of facial vermiform mite in some primary school pupils and middle school students in Haikou City. China Trop. Med., 6(8):1532–1533 (in Chinese).

    Google Scholar 

  • Yang, Z.H., Pan, B., Lin, R.X., Gu, S.H., 1998. Epidemiological study of human Demodex in Guangdong province. Guangdong J. Health Epidemic Prev., 24(4):1–3 (in Chinese).

    Google Scholar 

  • Yao, Z.L., 2005. Investigation of Demodex infection in Qingdao students. Chin. J. Parasitol. Parasit Dis., 23(4): 255 (in Chinese).

    Google Scholar 

  • Yuan, F.S., Guo, S.L., Han, Y.M., Deng, S.H., Huang, G.H., 2003. The curative effect of the cream made from the volatile oil of Chinese prickly ash on demodicidosis. Chin. J. Parasit. Dis. Con., 16(1):58–60 (in Chinese).

    Google Scholar 

  • Zhan, P.L., Shi, L.L., Sun, L., Zeng, R.R., 1997. Investigation of human Demodex infection in Hepu county. J. Guangxi Med. Univ., 14(1):146–147 (in Chinese).

    Google Scholar 

  • Zhang, H.Y., Shao, Z.P., Ding, Y.L., Xia, P., 2007. Investigation and relative factors analysis on Demodex infection in undergraduate students. J. Public Health Prev. Med., 18(1):65–66 (in Chinese).

    Google Scholar 

  • Zhang, J.S., Cui, J.G., Zhang, W.Z., Tang, H.W., 1985. Investigation of human Demodex infection. J. Hebei North Univ., 2:5–6 (in Chinese).

    Google Scholar 

  • Zhang, M.H., Xia, H., Hu, S.F., 2005. Investigation of Demodex infection in undergraduate students and observation of therapy. J. Trop. Dis. Parasitol., 3(4):213–215 (in Chinese).

    Google Scholar 

  • Zhang, X.S., Tong, X.L., Guo, Q., 1991. Investigation on Demodex infection of 1012 patients with skin disease. Chin. J. Parasit Dis. Con., 4(2):94 (in Chinese).

    Google Scholar 

  • Zhao, Y.E., Feng, L.P., Xun, M., Li, X.Q., Long, Q., 2004. Investigation on the infection of Demodex folliculorum and analysis on relative factors. Chin. J. Parasit Dis. Con., 17(1):56–57 (in Chinese).

    Google Scholar 

  • Zhao, Y.E., Guo, N., Wu, L.P., 2009. The effect of temperature on the viability of Demodex folliculorum and Demodex brevis. Parasitol. Res., 105(6):1623–1628. [doi:10.1007/s00436-009-1603-x]

    Article  PubMed  Google Scholar 

  • Zhao, Y.E., Wu, L.P., Peng, Y., Cheng, H., 2010. Retrospective analysis of the association between Demodex infestation and rosacea. Arch. Dermatol., 146(8):896–902. [doi:10.1001/archdermatol.2010.196]

    Article  PubMed  Google Scholar 

  • Zhao, Y.E., Guo, N., Xun, M., Xu, J.R., Wang, M., Wang, D.L., 2011a. Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae). J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 12(12): 998–1007. [doi:10.1631/jzus.B1100079]

    Article  Google Scholar 

  • Zhao, Y.E., Peng, Y., Wang, X.L., Wu, L.P., Wang, M., Yan, H.L., Xiao, S.X., 2011b. Facial dermatosis associated with Demodex: a case-control study. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 12(12):1008–1015. [doi:10.1631/jzus.B1100179]

    Article  Google Scholar 

  • Zhao, Y.E., Guo, N., Wu, L.P., 2011c. The influence of temperature and medium on viability of Demodex folliculorum and Demodex brevis (Acari: Demodicidae). Exp. Appl. Acarol., 54(4):421–425. [doi:10.1007/s10493-011-9445-5]

    Article  PubMed  Google Scholar 

  • Zhao, Y.E., Wu, L.P., Hu, L., Xu, J.R., 2012. Association of blepharitis with Demodex: a meta-analysis. Ophthal Epidemiol., in press. [doi:10.3109/09286586.2011.642052]

  • Zhou, D.S., Zhu, Z.Y., Deng, Z.Q., Liu, W.T., 2002. Investigation of humans Demodex infection in Xuwen county. Chin. J. Epdemiol., 23(1):31 (in Chinese).

    CAS  Google Scholar 

  • Zhou, H.Y., Zhao, Q.L., 2001. Investigation of Demodex infection in youth. Chin. J. Pest Con., 17(12):639–640 (in Chinese).

    Google Scholar 

  • Zhou, L., Wu, Y.J., 2003. Investigation on the infection of Demodex in college students. Chin. J. Parasit Dis. Con., 16(5):262 (in Chinese).

    Google Scholar 

  • Zou, M., Zhou, D.S., Dong, J.C., Luo, Y.D., Liu, W.T., Zhou, R.H., 2004. Investigation on the Demodex infection among 2475 students of middle and primary school. Chin. J. Parasit Dis. Con., 17(4):243–244 (in Chinese).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology and Pathogen Biology, Xi’an Jiaotong University College of Medicine, Xi’an, 710061, China

    Ya-e Zhao, Li Hu, Li-ping Wu & Jun-xian Ma

Authors
  1. Ya-e Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li-ping Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun-xian Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ya-e Zhao.

Additional information

Project supported by the National Natural Science Foundation of China (No. 30872199) and the Natural Science Foundation of Shaanxi Province (No. 2006C247), China

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhao, Ye., Hu, L., Wu, Lp. et al. A meta-analysis of association between acne vulgaris and Demodex infestation. J. Zhejiang Univ. Sci. B 13, 192–202 (2012). https://doi.org/10.1631/jzus.B1100285

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1631/jzus.B1100285

Key words

CLC number

Search

Navigation