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A Case of T-Cell Acute Lymphoblastic Leukemia after Treatment of Acute Promyelocytic Leukemia

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Abstract

We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.

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Authors and Affiliations

  1. Department of Medicine, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia

    P. C. Bee, G. G. Gan, J. V. Sangkar, A. Teh & K. Y. Goh

Authors
  1. P. C. Bee
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  2. G. G. Gan
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  3. J. V. Sangkar
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  4. A. Teh
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  5. K. Y. Goh
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Correspondence to P. C. Bee.

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Bee, P.C., Gan, G.G., Sangkar, J.V. et al. A Case of T-Cell Acute Lymphoblastic Leukemia after Treatment of Acute Promyelocytic Leukemia. Int J Hematol 79, 358–360 (2004). https://doi.org/10.1532/IJH97.A20304

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  • DOI: https://doi.org/10.1532/IJH97.A20304

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