International Journal of Hematology

, Volume 86, Issue 2, pp 137–142

Prevalence and Clinical Characteristics of Acute Myeloid Leukemia Associated with Disseminated Intravascular Coagulation

  • Hideki Uchiumi
  • Takafumi Matsushima
  • Arito Yamane
  • Noriko Doki
  • Hiroyuki Irisawa
  • Takayuki Saitoh
  • Tohru Sakura
  • Takahiro Jimbo
  • Hiroshi Handa
  • Norifumi Tsukamoto
  • Masamitsu Karasawa
  • Shuichi Miyawaki
  • Hirokazu Murakami
  • Yoshihisa Nojima
Article

DOI: 10.1532/IJH97.06173

Cite this article as:
Uchiumi, H., Matsushima, T., Yamane, A. et al. Int J Hematol (2007) 86: 137. doi:10.1532/IJH97.06173

Abstract

Disseminated intravascular coagulation (DIC) is one of the important complications to develop in patients with acute myeloid leukemia (AML). While acute promyelocytic leukemia (APL) is a strong risk factor for DIC, other clinical features have not been fully defined. We retrospectively analyzed 161 consecutive adult patients with de novo non-APL AML. DIC was diagnosed in 52 patients (32%); 28 patients at diagnosis and 24 soon after the initiation of induction chemotherapy. Leukocyte counts, C-reactive protein, and lactate dehydrogenase were significantly higher in the DIC+ group. Negative expressions of CD13, CD19, CD34, and HLA-DR were more prevalent in the DIC+ group. On multivariate logistic-regression analysis, variables that were independently associated with the development of DIC were high C-reactive protein, high leukocyte count, negative expressions of CD13 and HLA-DR, and cytogenetics with a normal karyotype or 11q23 abnormality. Although DIC is considered to be associated with serious morbidity and occasional mortality, we did not find any significant differences in the complete remission rate, overall or disease-free survival between DIC+ and DIC- groups. This study is the first to define the clinical characteristics associated with DIC in patients with non-APL AML, but exactly how and when DIC should be treated remains to be determined.

Key words

Acute myeloid leukemia DIC Cytogenetics CD13 HLA-DR 

Copyright information

© The Japanese Society of Hematology 2007

Authors and Affiliations

  • Hideki Uchiumi
    • 1
  • Takafumi Matsushima
    • 1
  • Arito Yamane
    • 2
  • Noriko Doki
    • 3
  • Hiroyuki Irisawa
    • 1
  • Takayuki Saitoh
    • 1
  • Tohru Sakura
    • 3
  • Takahiro Jimbo
    • 4
  • Hiroshi Handa
    • 5
  • Norifumi Tsukamoto
    • 1
  • Masamitsu Karasawa
    • 2
  • Shuichi Miyawaki
    • 3
  • Hirokazu Murakami
    • 5
  • Yoshihisa Nojima
    • 1
  1. 1.Department of Medicine and Clinical ScienceGunma University Graduate School of MedicineMaebashi, GunmaJapan
  2. 2.Division of Blood Transfusion ServiceGunma University HospitalGunmaJapan
  3. 3.Saiseikai Maebashi HospitalMaebashiJapan
  4. 4.Fujioka General HospitalGunmaJapan
  5. 5.School of Health Sciences Faculty of MedicineGunma UniversityGunmaJapan

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