Severe Hepatic Injury Caused by Imatinib Mesylate Administered for the Treatment of Chronic Myeloid Leukemia and the Efficacy of Prednisolone for its Management

  • Katsuya Ikuta
  • Yoshihiro Torimoto
  • Junko Jimbo
  • Junki Inamura
  • Motohiro Shindo
  • Kazuya Sato
  • Yoshihiko Tokusashi
  • Naoyuki Miyokawa
  • Yutaka Kohgo
Case Report

DOI: 10.1532/IJH97.05034

Cite this article as:
Ikuta, K., Torimoto, Y., Jimbo, J. et al. Int J Hematol (2005) 82: 343. doi:10.1532/IJH97.05034

Abstract

Imatinib mesylate is a specific inhibitor of BCR-ABL tyrosine kinase, which is now widely used for the treatment of chronic myeloid leukemia (CML) with a high efficacy. Although severe hepatic injury caused by imatinib mesylate is rare, such a side effect may force patients to discontinue taking imatinib mesylate. In the present paper, we report on the case of a 51-year-old woman with CML who experienced hepatic injury with severe hyperbilirubinemia caused by imatinib mesylate. The findings from a liver biopsy specimen and her clinical course suggested the hepatic injury to presumably have been caused by an allergic mechanism. The co-administration of prednisolone was thus tried, and she has been able to continue imatinib mesylate administration without any liver dysfunction and finally was able to obtain a complete cytogenetic response. We therefore recommend that prednisolone should be tried when severe hepatic injury caused by imatinib mesylate is observed, since it might enable such patients to continue imatinib mesylate treatment and thereby improve the prognosis in such cases.

Key words

Imatinib mesylate Hepatic injury Prednisolone Allergic mechanism Chronic myeloid leukemia (CML) 

Copyright information

© The Japanese Society of Hematology 2005

Authors and Affiliations

  • Katsuya Ikuta
    • 1
  • Yoshihiro Torimoto
    • 1
  • Junko Jimbo
    • 1
  • Junki Inamura
    • 1
  • Motohiro Shindo
    • 1
  • Kazuya Sato
    • 1
  • Yoshihiko Tokusashi
    • 2
  • Naoyuki Miyokawa
    • 2
  • Yutaka Kohgo
    • 1
  1. 1.Third Department of Internal MedicineAsahikawa Medical CollegeAsahikawaJapan
  2. 2.Department of Surgical PathologyAsahikawa Medical CollegeAsahikawaJapan

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