Philadelphia Chromosome—Positive Acute Lymphoblastic Leukemia Rescued with a Second Allogeneic Stem Cell Transplantation from a Haploidentical Mother after Relapse following Cord Blood Transplantation

  • Tatsuyuki Kai
  • Hideo Kimura
  • Yutaka Shiga
  • Shin Mineishi
  • Satoshi Yoshihara
  • Hiroyasu Ogawa
  • Etsuko Maruya
  • Hiroh Saji
  • Hitoshi Ohto
  • Yukio Maruyama
Case Report

DOI: 10.1532/IJH97.04072

Cite this article as:
Kai, T., Kimura, H., Shiga, Y. et al. Int J Hematol (2004) 80: 453. doi:10.1532/IJH97.04072
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Abstract

A 32-year-old female patient who had Philadelphia chromosome-positive acute lymphoblastic leukemia underwent cord blood transplantation while in her second remission. However, she had a hematological and central nervous system relapse 3 months later. After reinduction with imatinib mesylate, unmanipulated peripheral blood stem cell transplantation was performed from the patient’s haploidentical mother with a reduced-intensity conditioning regimen. Rabbit antithymocyte globulin, tacrolimus, and methylprednisolone were used for prophylaxis of graft-versus-host disease. Engraftment of neutrophils was observed on day 12, and complete donor chimerism was obtained by day 24. The posttransplantation course was uneventful. Although the patient had a relapse 10 months later, this case demonstrated that transplantation from a haploidentical donor is clearly a feasible alternative for patients who desperately need rescue transplantation.

Key words

Acute lymphoblastic leukemiaPhiladelphia chromosomeSecond stem cell transplantationHLA-mismatched hematopoietic stem cell transplantationFetomaternal microchimerismImatinib mesylate

Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Tatsuyuki Kai
    • 1
  • Hideo Kimura
    • 1
  • Yutaka Shiga
    • 1
  • Shin Mineishi
    • 2
  • Satoshi Yoshihara
    • 3
  • Hiroyasu Ogawa
    • 3
  • Etsuko Maruya
    • 4
  • Hiroh Saji
    • 4
  • Hitoshi Ohto
    • 5
  • Yukio Maruyama
    • 6
  1. 1.Hematology, Kita-Fukushima Medical CenterFukushimaJapan
  2. 2.Hematopoietic Stem Cell Transplantation UnitNational Cancer Center HospitalTokyo
  3. 3.Department of Molecular MedicineOsaka University Graduate School of MedicineOsaka
  4. 4.HLA LaboratoryKyoto
  5. 5.Division of Blood Transfusion and Transplantation ImmunologyFukushima Medical UniversityFukushimaJapan
  6. 6.First Department of Internal MedicineFukushima Medical UniversityFukushimaJapan