Abstract
Candida infections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida, strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay.
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Klunda, T., Machová, E., Čížzová, A. et al. Alkyl glycosides as potential anti-Candida albicans growth agents. Chem. Pap. 70, 1166–1170 (2016). https://doi.org/10.1515/chempap-2016-0051
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DOI: https://doi.org/10.1515/chempap-2016-0051