Immunologic Research

, Volume 32, Issue 1, pp 31–43

T-Cell stimulation and regulation: With complements from CD46

Authors

  • Claudia Kemper
    • Department of MedicineWashington University School of Medicine
  • James W. Verbsky
    • Department of Pediatrics, Division of RheumatologyWashington University School of Medicine
  • Jeffrey D. Price
    • Department of Graduate Program in ImmunologyWashington University School of Medicine
  • John P. Atkinson
    • Department of MedicineWashington University School of Medicine
Article

DOI: 10.1385/IR:32:1-3:031

Cite this article as:
Kemper, C., Verbsky, J.W., Price, J.D. et al. Immunol Res (2005) 32: 31. doi:10.1385/IR:32:1-3:031

Abstract

Crosslinking of CD46 and CD3 on naïve human CD4+ T-lymphocytes induces interleukin-10 secretion and granzyme B expression. These highly proliferative T-regulatory type 1-like T-regulatory T-cells (Tregs) can suppress an immune response. We propose that this process is important in the prevention of chronic inflammation such as at epithelial borders and in deactivation of a successful immune response. Relative to the latter, once a complement-fixing polyclonal antibody response has been mounted, in most cases, the pathogen will be rapidly destroyed. At this time, the C3b/C4b-bearing immune complexes could initiate the deactivation arm of an immune response by shutting down immunocompetent cells through CD46-generated T-cells. Herein, we review this pathway for the induction of Tregs, focusing on a role for the complement system and especially signaling through CD46 on human T-cells.

Key Words

CD46 Complement T-regulatory T-cells Immunosuppression Interleukin-10

Copyright information

© Humana Press Inc 2005