NeuroMolecular Medicine

, Volume 5, Issue 1, pp 85–108

Genes associated with addiction

Alcoholism, opiate, and cocaine addiction

Authors

    • Laboratory of the Biology of Addictive DiseasesThe Rockefeller University
  • David A. Nielsen
    • Laboratory of the Biology of Addictive DiseasesThe Rockefeller University
  • K. Steven LaForge
    • Laboratory of the Biology of Addictive DiseasesThe Rockefeller University
Article

DOI: 10.1385/NMM:5:1:085

Cite this article as:
Kreek, M.J., Nielsen, D.A. & LaForge, K.S. Neuromol Med (2004) 5: 85. doi:10.1385/NMM:5:1:085

Abstract

Drug addiction is a complex disorder that has a large spectrum of causes. Vulnerability to addiction has been shown in twin studies to have a robust genetic component. This genetic basis for addiction has general and specific components for each drug abused. Although many genes have been implicated in drug addiction, only a handful have either been replicated to have an association or to have an identified functional mechanism related to specific effects of abused drugs. A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article.

Index Entries

Addictionalcoholcocainegeneticsgenotypeopiatephysiogeneticsphysiogenomicspolymorphismsingle nucleotide polymorphism

Copyright information

© Humana Press Inc 2004