Medical Oncology

, Volume 22, Issue 2, pp 183–190

Bcl-xl expression in multiple myeloma

  • S. D. P. W. M. Peeters
  • S. Hovenga
  • S. Rosati
  • E. Vellenga
Original Article

DOI: 10.1385/MO:22:2:183

Cite this article as:
Peeters, S.D.P.W.M., Hovenga, S., Rosati, S. et al. Med Oncol (2005) 22: 183. doi:10.1385/MO:22:2:183

Abstract

In the present study the immunohistochemical expression of Bcl-xl, a downstream target of the IL-6-controlled signal transducer and activator of transcription-3 (Stat3) was studied in 40 multiple myeloma (MM) cases before treatment and 11 MM patients at relapse. Correlation analysis was performed between Bcl-xl expression, C-reactive protein (CRP) level, beta-2-microglobulin (β2m), microvessel density (MVD), and clinical outcome. Before treatment 28 (70%) patients demonstrated a Bcl-xl expression similar to normal plasma cells (“normal pattern”), while 12 (30%) patients demonstrated an elevated expression in a subgroup of the malignant plasma cells. At relapse, no change in Bcl-xl expression was observed as compared to pretreatment sample. No correlation was observed between the Bcl-xl expression and the level of CRP and b2m. In addition, no significant correlation was observed between the Bcl-xl expression and the MVD, but MVD was significantly increased as compared to normal bone marrow biopsy specimens (p=0.02). Patients with an elevated or normal Bcl-xl expression showed no statistically significant difference in overall and event-free survival. In summary, these data indicate that Bcl-xl is elevated in a subgroup of MM patients that so far did not correlate with CRP, b2m, MVD, and clinical outcome.

Key Words

Bcl-xlmultiple myelomaMVD

Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • S. D. P. W. M. Peeters
    • 1
  • S. Hovenga
    • 1
  • S. Rosati
    • 2
  • E. Vellenga
    • 1
  1. 1.Department of HematologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Department of PathologyUniversity Hospital GroningenGroningenThe Netherlands