Case Report

Medical Oncology

, Volume 19, Issue 2, pp 117-119

First online:

Flutamide-induced acute renal failure in a patient with metastatic prostate cancer

  • Mehmet Riza AltiparmakAffiliated withDepartment of Nephrology, Cerrahpasa School of Medicine, Istanbul University
  • , Ahmet BiliciAffiliated withDepartment of Internal Medicine, Cerrahpasa School of Medicine, Istanbul University
  • , Bunyamin KisacikAffiliated withDepartment of Internal Medicine, Cerrahpasa School of Medicine, Istanbul University
  • , Mustafa OzgurogluAffiliated withDepartment of Medical Oncology, Cerrahpasa School of Medicine, Istanbul University

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Abstract

Androgen blockage, with either orchiectomy or luteinizing hormone releasing hormone (LHRH) analogs combined with an antiandrogen drug, is the standard treatment for metastatic prostate cancer. Flutamide is a nonsteroidal antiandrogen drug that is frequently used for total androgen blockage. We report on a 54-yr-old man with metastatic prostate cancer who developed nonoliguric acute renal failure (ARF) during treatment with flutamide. Following discontinuation of flutamide therapy, his renal functions returned to normal limits within 4 wk. After a rechallenge with flutamide, serum levels of BUN and creatinine increased again. His renal function recovered completely after the cessation of the drug for the second time. This observation confirm that ARF may be clearly attributed to flutamide therapy. Although very rare, flutamide-induced ARF should be considered.

Key Words

Flutamide acute renal failure prostate cancer