Molecular Neurobiology

, Volume 32, Issue 2, pp 133–144

Interactions of interleukin-1 with neurotrophic factors in the central nervous system

Beneficial or detrimental?

DOI: 10.1385/MN:32:2:133

Cite this article as:
Friedman, W.J. Mol Neurobiol (2005) 32: 133. doi:10.1385/MN:32:2:133


Interleukin (IL)-1 is a multifunctional cytokine that plays a key role in mediating inflammation in the brain. Many different cell types in the brain express the IL-1 receptor and respond to this cytokine by activating cell-type-specific signaling pathways leading to distinct functional responses, which collectively comprise the inflammatory response in the brain. One key effect of IL-1 in the brain is the induction of trophic factor production by glial cells, which has traditionally been considered a neuroprotective response to injury or disease. However, recent studies have shown that nerve growth factor, which is regulated by IL-1, can induce neuronal survival or apoptosis via different receptors. This article examines the interaction of IL-1 with different trophic factors in the brain.

Index Entries

Interleukin (IL)-1nerve growth factor (NGF)brain inflammationneurotrophin (NT)apoptosis

Copyright information

© The Humana Press Inc 2005

Authors and Affiliations

  1. 1.Department of Biological SciencesRutgers UniversityNewark