Molecular Neurobiology

, Volume 26, Issue 2, pp 137–152

Molecular aspects of vertebrate retinal development


  • Samuel Shao-Min Zhang
    • Department of PathologyYale University School of Medicine
  • Xin-Yuan Fu
    • Department of PathologyYale University School of Medicine
    • Department of Ophthalmology and Visual ScienceYale University School of Medicine
    • Department of NeurobiologyYale University School of Medicine

DOI: 10.1385/MN:26:2-3:137

Cite this article as:
Zhang, S.S., Fu, X. & Barnstable, C.J. Mol Neurobiol (2002) 26: 137. doi:10.1385/MN:26:2-3:137


The formation of retina from neural plate has been mapped extensively by anatomical and molecular methods. The major cascades of transcription factor expression have been identified, and deficits resulting from transcription factor knockouts are well characterized. There is extensive cross-regulation, both positive and negative, at the transcriptional level between transcription factors and this is vital in the formation of neural compartments. Many transcription factors are important at both early stages of optic cup formation and later stages of terminal differentiation of retinal cell types. The transcription factor cascades can be regulated by extrinsic factors, and some of the intracellular signaling pathways whereby this is achieved have been identified. Defining the quantitative interactions between regulatory molecules will be the next step in understanding this excellent model of vertebrate central nervous system (CNS) development.

Index Entries

Transcription factor optic vesicle optic cup photoreceptor neurogenesis

Copyright information

© Humana Press Inc 2002