Molecular Neurobiology

, Volume 21, Issue 1, pp 83–95

The cerebral proteopathies

Neurodegenerative disorders of protein conformation and assembly
  • Lary C. Walker
  • Harry LeVine

DOI: 10.1385/MN:21:1-2:083

Cite this article as:
Walker, L.C. & LeVine, H. Mol Neurobiol (2000) 21: 83. doi:10.1385/MN:21:1-2:083


The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly. These “cerebral proteopathies” include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic strategies that reduce the production, accumulation, or polymerization of pathogenic proteins might be applicable to a wide range of some of the most devastating diseases of old age.

Index Entries

Aging Alzheimer’s disease amyloid amyotrophic lateral sclerosis dementia diabetes Huntington’s disease Parkinson’s disease prion proteopathy 

Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • Lary C. Walker
    • 1
  • Harry LeVine
    • 1
  1. 1.Neuroscience Therapeutics, Pfizer Ann Arbor LaboratoriesAnn Arbor

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