Molecular Biotechnology

, Volume 20, Issue 3, pp 261–283

Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim, and sulfonamide drug classes


DOI: 10.1385/MB:20:3:261

Cite this article as:
Roberts, M.C. Mol Biotechnol (2002) 20: 261. doi:10.1385/MB:20:3:261


The discovery and use of antimicrobial agents in the last 50 yr has been one of medicine’s greatest achievements. These agents have reduced morbidity and mortality of humans and animals and have directly contributed to human’s increased life span. However, bacteria are becoming increasingly resistant to these agents by mutations, which alter existing bacterial proteins, and/or acquisition of new genes, which provide new proteins. The latter are often associated with mobile elements that can be exchanged quickly across bacterial populations and may carry multiple antibiotic genes fo resistance. In some case, virulence factors are also found on these same mobile elements. There is mounting evidence that antimicrobial use in agriculture, both plant and animal, and for environmental purposes does influence the antimicrobial resistant development in bacteria important in humans and in reverse. In this article, we will examine the genes which confer resistance to tetracycline, macrolide-lincosamide-streptogramin (MLS), trimethoprim, and sulfonamide.

Index Entries

Tetracycline macrolide-lincosamide-streptogramin trimethoprim sulfonamide resistance genes 

Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  1. 1.Department of Pathobiology, Box 357238, School of Public Health and Community MedicineUniversity of WashingtonSeattle

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