Molecular Biotechnology

, Volume 12, Issue 3, pp 241–253

Protein consensus sequence motifs

Authors

    • Department of Biomedical Sciences (Biochemistry)University of Edinburgh, George Square
Review

DOI: 10.1385/MB:12:3:241

Cite this article as:
Aitken, A. Mol Biotechnol (1999) 12: 241. doi:10.1385/MB:12:3:241

Abstract

The large number of protein consensus sequences that may be recognized without computer analysis are reviewed. These include the extensive range of known phosphorylation site motifs for protein kinases; metal binding sites for calcium, zinc, copper, and iron; enzyme active site motifs; nucleotide binding and covalent attachment sites for prosthetic groups, carbohydrate, and lipids. Of particular note is the increasing realization of the importance for cellular regulation of protein-protein interaction motifs and sequences that target proteins to particular subcellular locations. This article includes an introduction to accessing the many suites of programs for analysis of protein structure, signatures of protein families, and consensus sequences that may be carried out on the internet.

Index Entries

Protein consensus sequencesmotifsprotein-protein interactionposttransitional modification

Copyright information

© Humana Press Inc. 1999