Journal of Molecular Neuroscience

, Volume 27, Issue 3, pp 311–314

No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy

Authors

  • Giulia Bellini
    • Chair of Child NeuropsychiatrySecond University of Naples
    • Department of PediatricsSecond University of Naples
  • Carmela Bravaccio
    • Chair of Child NeuropsychiatrySecond University of Naples
  • Filippo Calamoneri
    • Chair of Child NeuropsychiatryUniversity of Messina
  • Maria Donatella Cocuzza
    • Chair of Child NeuropsychiatryUniversity of Catania
  • Pasquale Fiorillo
    • Centro Serapide
  • Antonella Gagliano
    • Chair of Child NeuropsychiatryUniversity of Messina
  • Domenico Mazzone
    • Chair of Child NeuropsychiatryUniversity of Catania
    • Department of PediatricsSecond University of Naples
  • Geoffredo Scuccimarra
    • Istituto Antoniano
  • Roberto Militerni
    • Chair of Child NeuropsychiatrySecond University of Naples
  • Antonio Pascotto
    • Chair of Child NeuropsychiatrySecond University of Naples
Original Article

DOI: 10.1385/JMN:27:3:311

Cite this article as:
Bellini, G., Bravaccio, C., Calamoneri, F. et al. J Mol Neurosci (2005) 27: 311. doi:10.1385/JMN:27:3:311

Abstract

Recently, DYX1C1, a candidate gene for developmental dyslexia, encoding a nuclear tetratricopepetide repeat domain protein dynamically regulated in brain, has been characterized through a translocation breakpoint in a Finnish family. Two putatively functional variants, −3G/A and 1249G/T, have been reported to be significantly associated with dyslexia in this population. Further studies, conducted on different ethnic groups (English and Canadian), have not confirmed a role for DYX1C1 variants in increasing the risk for dyslexia. We investigated the role of these variants in dyslexic children and adolescents from Southern Italy. No significant evidence for association between dyslexia and these DYX1C1 putative functional variants has been shown. We argue that the different DYX1C allele frequencies shown among Italian and Finnish subjects with dyslexia could be attributable to the different linkage disequilibrium structure of these populations.

Index Entries

EKN1reading disabilitiesSNPs15q21dyslexiaDYX1C1

Copyright information

© Humana Press Inc 2005