Journal of Molecular Neuroscience

, Volume 18, Issue 1, pp 143–149

Venlafaxine and mirtazapine

Different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects—A possible opioid involvement in severe depression?
Protein Processing And Trafficking, Pain, Depression, And Anxiety

DOI: 10.1385/JMN:18:1-2:143

Cite this article as:
Schreiber, S., Bleich, A. & Pick, C.G. J Mol Neurosci (2002) 18: 143. doi:10.1385/JMN:18:1-2:143


The efficacy of each antidepressant available has been found equal to that of amitriptyline in double-blind studies as far as mild to moderate depression is involved. However, it seems that some antidepressants are more effective than others in the treatment of severe types of depression (i.e., delusional depression and refractory depression). Following studies regarding the antinociceptive mechanisms of various antidepressants, we speculate that the involvement of the opioid system in the antidepressants’ mechanism of action may be necessary, in order to prove effective in the treatment of severe depression. Among the antidepressants of the newer generations, that involvement occurs only with venlafaxine (a presynaptic drug which blocks the synaptosomal uptake of noradrenaline and serotonin and, to a lesser degree, of dopamine) and with mirtazapine (a postsynaptic drug which enhances noradrenergic and 5-HT1A-mediated serotonergic neurotransmission via antagonism of central α2-auto- and hetero-adrenoreceptors). When mice were tested with a hotplate analgesia meter, both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following ip administration. Summing up the various interactions of venlafaxine and mirtazapine with opioid, noradrenergic and serotonergic agonists and antagonists, we found that the antinociceptive effect of venlafaxine is influenced by opioid receptor subtypes (μ-, κ1- κ3- and δ-opioid receptor subtypes) combined with the α2-adrenergic receptor, whereas the antinociceptive effect of mirtazapine mainly involves μ- and κ3-opioid mechanisms. This opioid profile of the two drugs may be one of the explanations to their efficacy in severe depression, unlike the SSRIs and other antidepressants which lack opioid activity.

Index Entries

Antidepressantsantinociceptiondelusional depressionhotplateopioid receptor subtypesnoradrenalinemirtazapinerefractory depressionserotoninvenlafaxine

Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  1. 1.Department of PsychiatryTel Aviv Sourask Medical Center, and Tel-Aviv University Sackler School of MedicineTel-AvivIsrael
  2. 2.Department of Anatomy and AnthropologyTel-Aviv University Sackler School of MedicineTel-AvivIsrael