Immunologic Research

, Volume 36, Issue 1, pp 27–32

From B cell to plasma cell

Regulation of V(D)J recombination and antibody secretion
  • Lisa Borghesi
  • Christine Milcarek

DOI: 10.1385/IR:36:1:27

Cite this article as:
Borghesi, L. & Milcarek, C. Immunol Res (2006) 36: 27. doi:10.1385/IR:36:1:27


B cell development culminates in the formation of plasma cells, potent secretors of the immunoglobulins (Ig), proteins crucial for the health of the organism. Two distinctive and crucial steps are required during B cell differentiation. First, variable gene segments encoding the antigen-binding region of Ig undergo directed rearrangement through a process known as V(D)J recombination. Second, alternative processing of the Ig heavy chain mRNA transcript enables plasma cells to secrete high levels of Ig protein. This review focuses on the molecular mechanisms that control V(D)J recombination in B cell progenitors and alternative RNA processing in plasma cells.

Key Words

V(D)J recombinationE47HematopoiesishnRNP FCstF-64Plasma cell

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Lisa Borghesi
    • 1
  • Christine Milcarek
    • 1
  1. 1.Department of ImmunologyUniversity of Pittsburgh School of MedicinePittsburgh