Immunologic Research

, Volume 36, Issue 1, pp 247–254

Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles

Article

DOI: 10.1385/IR:36:1:247

Cite this article as:
Wieckowski, E. & Whiteside, T.L. Immunol Res (2006) 36: 247. doi:10.1385/IR:36:1:247

Abstract

Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.

Key Words

Exosomes Microvesicles Human tumors Dendritic cells T cells Apoptosis 

Copyright information

© Human Press Inc 2006

Authors and Affiliations

  1. 1.Department of Pathology, Immunology and OtolaryngologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Hillman Cancer CenterUniversity of Pittsburgh Cancer InstitutePittsburgh