Immunologic Research

, Volume 21, Issue 2, pp 149–158

Regulation of development and function of memory CD4 subsets

Authors

  • Linda M. Bradley
    • Department of Immunology, IMM-23The Scripps Research Institute
  • Judith Harbertson
    • Department of Immunology, IMM-23The Scripps Research Institute
  • Gina C. Freschi
    • Department of Immunology, IMM-23The Scripps Research Institute
  • Robyn Kondrack
    • Department of Immunology, IMM-23The Scripps Research Institute
  • Phyllis J. Linton
    • The Sidney Kimmel Cancer Center
Article

DOI: 10.1385/IR:36:1:149

Cite this article as:
Bradley, L.M., Harbertson, J., Freschi, G.C. et al. Immunol Res (2000) 21: 149. doi:10.1385/IR:36:1:149
  • 21 Views

Abstract

Immunologic memory refers to the dramatic response to previously encountered antigen (Ag) that is largely controlled by CD4 T cells. Understanding how CD4 memory is regulated isessential for exploiting the immune system to protect against disease and to dampen immunopathology in allergic responses and autoimmunity. Using defined adoptive-transfer models, we are studying parameters that affect differentiation of memory CD4 cells in vivo and have found that a complex interplay of T cell receptor signaling, costimulation, and cytokinesc an determine the extent of memory development and the balance of Th1 and Th2 memory subsets. On challenge, memory CD4 cells localize in sites of Ag exposure and develop into effectors that regulate memory responses. We are investigating the roles of adhesion molecules, cytokines, and chemokines in the selective recruitment of CD4 memory subsets to address mechanisms by which memory T cells provide long-lasting immunity and, in our recent studies, to determine how memory CD4 cells contribute to the development of autoimmune diabetes.

Key Words

Immunologic memoryCD4 subsetsCytokinesChemokinesInflammationRecruitmentAutoimmune diabetes

Copyright information

© Humana Press Inc. 2000