Article

Immunologic Research

, Volume 21, Issue 2, pp 149-158

Regulation of development and function of memory CD4 subsets

  • Linda M. BradleyAffiliated withDepartment of Immunology, IMM-23, The Scripps Research Institute
  • , Judith HarbertsonAffiliated withDepartment of Immunology, IMM-23, The Scripps Research Institute
  • , Gina C. FreschiAffiliated withDepartment of Immunology, IMM-23, The Scripps Research Institute
  • , Robyn KondrackAffiliated withDepartment of Immunology, IMM-23, The Scripps Research Institute
  • , Phyllis J. LintonAffiliated withThe Sidney Kimmel Cancer Center

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Abstract

Immunologic memory refers to the dramatic response to previously encountered antigen (Ag) that is largely controlled by CD4 T cells. Understanding how CD4 memory is regulated isessential for exploiting the immune system to protect against disease and to dampen immunopathology in allergic responses and autoimmunity. Using defined adoptive-transfer models, we are studying parameters that affect differentiation of memory CD4 cells in vivo and have found that a complex interplay of T cell receptor signaling, costimulation, and cytokinesc an determine the extent of memory development and the balance of Th1 and Th2 memory subsets. On challenge, memory CD4 cells localize in sites of Ag exposure and develop into effectors that regulate memory responses. We are investigating the roles of adhesion molecules, cytokines, and chemokines in the selective recruitment of CD4 memory subsets to address mechanisms by which memory T cells provide long-lasting immunity and, in our recent studies, to determine how memory CD4 cells contribute to the development of autoimmune diabetes.

Key Words

Immunologic memory CD4 subsets Cytokines Chemokines Inflammation Recruitment Autoimmune diabetes