Immunologic Research

, Volume 35, Issue 3, pp 295–302

Regulations and roles of the interleukin-1 receptor associated kinases (IRAKs) in innate and adaptive immunity

Authors

  • Lu Gan
    • Laboratory of Innate Immunity and Inflammation, Department of BiologyVirginia Tech
    • Laboratory of Innate Immunity and Inflammation, Department of BiologyVirginia Tech
Article

DOI: 10.1385/IR:35:3:295

Cite this article as:
Gan, L. & Li, L. Immunol Res (2006) 35: 295. doi:10.1385/IR:35:3:295

Abstract

The interleukin-1 receptor associated kinases (IRAKs) are critically involved in the IL-1R/Toll-like receptor (TLR)-mediated signal transduction processes and therefore regulate, cellular innate immune responses. Four IRAK members have been identified in the human genome (IRAK-1, 2, M, and 4), which seem to play distinct roles. Recent studies further suggest that some of the IRAK members may also participate in T cell and B cell signaling and regulate adaptive immunity. Given the critical and complex roles IRAK proteins play, it is not surprising that genetic variations in human IRAK genes have been found to be linked with various human inflammatory diseases. This review intends to summarize the recent advances regarding the biochemical regulations of various IRAK proteins and their cellular functions in mediating innate and adaptive immunity.

Key Words

IRAKInnate immunitySignalingTLRHuman diseases
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Copyright information

© Humana Press Inc. 2006